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Aerosol Science and Technology Volume 45, 2011 - Issue 1
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Regular Articles

Micronized Drug Adhesion and Detachment from Surfaces: Effect of Loading Conditions

Parthiban Selvam College of Pharmacy, University of Texas at Austin, Austin, Texas, USA
,
Steve Marek College of Pharmacy, University of Texas at Austin, Austin, Texas, USA
,
C. Randall Truman School of Engineering, University of New Mexico, Albuquerque, New Mexico, USA
,
Doug McNair Cerner Corporation, Kansas City, Kansas, USA
&
Hugh D.C. Smyth College of Pharmacy, University of Texas at Austin, Austin, Texas, USA
Pages 81-87 | Received 20 Apr 2010, Accepted 09 Aug 2010, Published online: 09 Jun 2011

Figures & data

FIG. 1 Prototype of flutter based DPI. (Figure provided in color online.)

FIG. 1 Prototype of flutter based DPI. (Figure provided in color online.)

FIG. 2 Experimental set-up of drug loading mechanism. (Figure provided in color online.)

FIG. 2 Experimental set-up of drug loading mechanism. (Figure provided in color online.)

FIG. 3 SEM image of Budesonide drug particles.

FIG. 3 SEM image of Budesonide drug particles.

FIG. 4 AFM images of polyolefin film surface. (a) Top surface; (b) bottom surface of the film.

FIG. 4 AFM images of polyolefin film surface. (a) Top surface; (b) bottom surface of the film.

TABLE 1 Effect of time on drug loading

FIG. 5 Effect of beads on the drug loading onto polyolefin film at various times. The times investigated are 1, 10, and 30 min. (Figure provided in color online.)

FIG. 5 Effect of beads on the drug loading onto polyolefin film at various times. The times investigated are 1, 10, and 30 min. (Figure provided in color online.)

FIG. 6 % Budesonide removed as a function of beads and mixing time. (Figure provided in color online.)

FIG. 6 % Budesonide removed as a function of beads and mixing time. (Figure provided in color online.)

FIG. 7 Effect of mixing times on aerosol performance using TSI. Drug loading was performed using plastic beads. (Figure provided in color online.)

FIG. 7 Effect of mixing times on aerosol performance using TSI. Drug loading was performed using plastic beads. (Figure provided in color online.)

TABLE 2 Aerosol characteristics of the dispersion as a function of beads and drug loading time

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Related Research Data

Interfacial tension approach toward drug loading with two-dimensional crosslinked polymer embedded gold: Adsorption kinetics evaluation
Source: Informa UK Limited

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