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Articles

Deposition of micrometer-sized aerosol particles in neonatal nasal airway replicas

, ORCID Icon, ORCID Icon, , & ORCID Icon
Pages 407-419 | Received 02 Oct 2017, Accepted 28 Nov 2017, Published online: 29 Dec 2017

Figures & data

Table 1. Subject demographics and airway characteristics.

Table 2. Breath defining parameters.

Figure 1. Schematic of experimental apparatus.

Figure 1. Schematic of experimental apparatus.

Figure 2. Comparison of deposition in population of neonate models (this study) to deposition in the population of infant nasal airways (Storey-Bishoff et al. Citation2008) and to deposition in a 10 day old infant (Zhou et al. Citation2014).

Figure 2. Comparison of deposition in population of neonate models (this study) to deposition in the population of infant nasal airways (Storey-Bishoff et al. Citation2008) and to deposition in a 10 day old infant (Zhou et al. Citation2014).

Figure 3. Deposition for each neonate nasal model as a function of impaction parameter.

Figure 3. Deposition for each neonate nasal model as a function of impaction parameter.

Figure 4. Deposition as a function of pressure-drop-based impaction parameter.

Figure 4. Deposition as a function of pressure-drop-based impaction parameter.

Figure 5. Deposition measured in neonatal nasal airways compared to the correlation developed by Storey-Bishoff et al. (Citation2008) for deposition measured in infants (r2 = 0.47).

Figure 5. Deposition measured in neonatal nasal airways compared to the correlation developed by Storey-Bishoff et al. (Citation2008) for deposition measured in infants (r2 = 0.47).

Table 3. Summary of r2 values for each characteristic diameter. Values of α, β, γ are different in each case found using non-linear least squares fitting.

Figure 6. Deposition in neonatal nasal airways vs. non-dimensional deposition parameter, characteristic diameter defined D = V/AS, fit defined in EquationEquation (9), r2 = 0.97.

Figure 6. Deposition in neonatal nasal airways vs. non-dimensional deposition parameter, characteristic diameter defined D = V/AS, fit defined in EquationEquation (9)[9] , r2 = 0.97.

Figure 7. Neonatal nasal deposition as a function of Stokes number, characteristic diameter defined D = V/AS, fit defined in EquationEquation (10), r2 = 0.69.

Figure 7. Neonatal nasal deposition as a function of Stokes number, characteristic diameter defined D = V/AS, fit defined in EquationEquation (10)[10] , r2 = 0.69.

Table 4. Total deposition (on a mass basis) of aerosol with MMAD of 3.7 µm and GSD of 2.

Figure 8. Predicted deposition (using EquationEquation (10)) versus in-vitro measured deposition. Solid line indicates line of identity; dashed lines bound 95% of the data.

Figure 8. Predicted deposition (using EquationEquation (10)[10] ) versus in-vitro measured deposition. Solid line indicates line of identity; dashed lines bound 95% of the data.

Table 5. Comparison of average and variability in total deposition in adults (Ruzycki et al. Citation2017) and neonatal infants (in vitro) when normally inhaling an aerosol with MMAD 3.7 µm and GSD of 2.

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