Retrospective study of men with E. coli UTI treated with an oral antibiotic, and risk for a new prescription or hospital admission due to UTI

Figures & data

Table 1. The age distribution, resistance pattern and outcome of non-fluoroquinolones used for UTI in men in the Capital Region of Denmark between 1 January 2010 and 30 September 2016.

Empirical Antibiotic	Cases	Proportion 18–50 years (%)	Proportion 51–70 years (%)	Proportion > 70 years (%)	Absolute treatment failure (%)	Resistant to the redeemed empirical antibiotic (%)	Percent resistant bacteria in treatment failure group (%)	Hazard ratio 30-day treatment failure^a (98.75% CI)	p Value	Hazard ratio 30-day treatment failure^b (98.75% CI)	p Value
Trimethoprim 7 d	98	13	34	51	25	14	9/25 (36.0)	Reference	–	Reference	–
		(13.3)	(34.7)	(52.0)	(25.5)	(14.3)
Pivmecillinam 5 d	903	219	357	327	376	27	15/376 (4,0)	2.05	<.001	1.92	.001
		(24.3)	(39.5)	(36.2)	(41.6)	(3.0)		(1.25–3.37)		(1.17–3.15)
Pivmecillinam 7 d	1291	293	490	508	529	47	27/529 (5.1)	1.96	.001	1.84	.003
		(22.7)	(38.0)	(39.4)	(41.0)	(3.6)		(1.20–3.20)		(1.13–3.00)
Nitrofurantoin 7 d	91	8	30	53	43	3	3/43 (7.0)	2.34	<.001	2.15	.002
		(8.8)	(33.0)	(58.2)	(47.3)	(3.3)		(1.28–4.27)		(1.18–3.91)

^a Adjusted for age and resistance.

^b Adjusted for age. Level of significance = 0.017 due to multiple comparison.