Classifying and communicating risks in prediabetes according to fasting glucose and/or glycated hemoglobin: PREDAPS cohort study

Figures & data

Table 1. People at the beginning of follow-up, person-years of follow-up, and sex and age-adjusted incidence rates of diabetes and regression to normoglycemia per 1000 person-years according prediabetes category.

Prediabetes category	People at the beginning of follow-up	Person-years of follow-up	Incidence rate of diabetes (95% CI)		Incidence rate of regression (95% CI)
Isolated FPG 100–109 mg/dL	152	680	6.8	(0.6–13.0)	74.8	(55.0–100.9)
Isolated FPG 110–125 mg/dL	102	426	38.4	(20.5–56.3)	36.2	(19.3–55.8)
Isolated HbA1c 5.7–5.9%	204	941	9.9	(3.7–16.1)	84.5	(66.2–103.9)
Isolated HbA1c 6.0–6.4%	112	501	19.3	(6.5–32.2)	38.7	(5.9–50.0)
FPG 100-109 mg/dL & HbA1C 5.7–5.9 %	138	600	35.2	(18.6–51.8)	29.0	(16.4–43.6)
FPG 100-109 mg/dL & HbA1C 6.0–6.4 %	128	524	52.8	(30.3–75.3)	23.2	(5.3–36.7)
FPG 110-125 mg/dL &HbA1C 5.7–5.9 %	140	579	55.5	(36.1–74.8)	30.3	(14.6–44.1)
FPG 110-125 mg/dL &HbA1C 6.0–6.4 %	208	671	132.3	(103.9–160.8)	12.9	(2.8–21.0)
Overall	1184	4922	42.8	(37.0–48.6)	43.9	(38.1–49.8)

95% CI: 95% confidence interval.

Table 2. Sex and age-adjusted probabilities of diabetes non-onset and onset, odds of diabetes non-onset versus onset and sex and age-adjusted probability of reversion to normoglycemia.

Prediabetes category	Diabetes
	Probability (%) of diabetes non-onset (95% CI)		Probability (%) of diabetes onset (95% CI)		Odds of non-onset versus onset (95% Cl)	Probability (%) of reversion to normoglycemia (95% CI)
Isolated FPG 100–109 mg/dL	96.7	(93.7–99.7)	3.3	(0.3–6.3)	29: 1	31.2	(24.0–39.6)
Isolated FPG 110–125 mg/dL	82.5	(75.5–90.3)	17.5	(9.7–24.5)	5: 1	16.6	(9.2–24.3)
Isolated HbA1c 5.7–5.9%	95.2	(92.3–98.2)	4.8	(1.8–7.7)	20: 1	34.5	(28.2–40.5)
Isolated HbA1c 6.0–6.4%	90.8	(85.1–96.8)	9.2	(3.2–14.9)	10: 1	17.6	(2.9–22.1)
FPG 100–109 mg/dL & HbA1C 5.7–5.9 %	83.9	(77.2–91.1)	16.1	(8.9–22.8)	5: 1	13.5	(7.9–19.6)
FPG 100–109 mg/dL & HbA1C 6.0–6.4 %	76.8	(68.8–83.5)	23.2	(14.1–31.4)	3: 1	11.0	(2.6–16.8)
FPG 110–125 mg/dL &HbA1C 5.7–5.9 %	75.8	(68.6–85.9)	24.2	(14.1–31.4)	3: 1	14.1	(7.0–19.8)
FPG 110–125 mg/dL &HbA1C 6.0–6.4 %	51.6	(44.8–59.5)	48.4	(40.5–55.2)	1: 1	6.2	(1.4–10.0)
Overall	80.7	(78.4–83.1)	19.3	(16.9–21.6)	4: 1	19.7	(17.3–22.0)

95% CI: 95% Confidence interval. PREDAPS Study. 1. Probability of diabetes non-onset versus onset.

Figure 1. Pictograms to explain the prognosis of prediabetes per 100 people at five years’ follow-up in each prediabetes category in the PREDAPS study. Probability of diabetes non-onset versus onset, and number of people who revert to normoglycemia, continue with prediabetes , and who develop diabetes .