Abstract
Purpose: To investigate changes in renal dimensions during long-term treatment with ciclosporin-A (CsA).
Material and Methods: Five mini-Göttingen pigs were treated with CsA (10 mg kg−1day−1) for 6 months; 3 untreated animals served as controls. Renal length was measured by magnetic resonance imaging (MRI) and ultrasonography (US); renal volume by MRI. Examinations were performed at baseline (0 weeks) and after the start of CsA treatment at intervals of 5 weeks (5–25 weeks).
Results: Comparison of baseline and end-point data (0 weeks vs. 25 weeks) revealed a statistically significant increase in renal volume in CsA-treated animals (87.1 cm3 vs. 55.9 cm3, P = 0.002). Renal volume remained unchanged in the control group. A significant increase in renal length was found both in the CsA-treated pigs (MRI: 96 mm vs. 84 mm, P<0.001; US: 94 mm vs. 81 mm, P<0.001) and in the control group (MRI: 97 mm vs. 85 mm, P<0.001; US: 89 mm vs. 81 mm, P = 0.018). No difference was found between MRI and US measurements based on 40 paired units (MRI variance: 2.4–30.3% and US variance: −5.1–40.6%, P = 0.133).
Conclusion: During long-term CsA treatment, renal volume increases in mini-pigs, but there is no correlation between the increase in volume and the increase in length in this pig model.