Metastatic granular cell tumor: A case report and review of the literature

Figures & data

Table I.  Clinical features of metastatic granular cell tumor cases.

Ref #	Age	Sex	Primary tumor site	Metastases	Treatment modality	DFS	OS
[1]	72	M	Subglottic mass	Lung	S + CT	0	14 +
[2]	37	F	Tongue	Local recurrence	S	72	72 +
[3]	26	F	Lower leg	Local recurrence	S	24	24 +
[3]	18	F	Lower back	Local recurrence	S	12	12 +
[3]	36	F	Leg	?		12	12 +
[3]	38	F	Buttock	Lymph nodes	S	24	24 +
[3]	41	F	Neck	Lymph nodes	S	12	12 +
[3]	41	F	Shoulder	Local recurrence, heart, pleura, lung		12	24
[3]	41	F	Groin	Local recurrence, bone, brain	S	12	48
[3]	42	M	Finger	?	S	12	24
[3]	49	M	Chest wall	Local recurrence, lung	S	48	108
[3]	56	F	Vulva	Lymph nodes	S	24	24 +
[3]	58	F	Larynx	Local recurrence, distant metastasis	S	24	36
[3]	56	F	Upper Arm	Lung, liver, bone, thyroid	S	24	24
[3]	56	F	Chest wall	Bone, lung	S	12	24
[3]	69	F	Chest wall	Lung	S	48	96
[3]	70	F	Axilla	Local recurrence, lung	S	60	96
[3]		M	Thigh	Lung	S	48	48 +
[4]	41	F	Hard palate	Local recurrence	S	54	54 +
[5]	?	M	Abdominal wall	Liver, lung	S	?	5
[5]	?	M	Breast	Liver, lung, bone	CT	?	7
[6]	21	F	Retroceacal space	Lung	S	0	7
[7]	72	M	Cervical region	Lymph node, eye, lung, bone	S	24	84
[8]	42	M	Lateral cutaneous nerve	Lung, liver, bone	S + CT	–	6 +
[9]	57	F	Pararectal mass	Liver	S	8	11
[10]	55	F	Vulva	Lung, liver, bone	S	4	4
[11]	72	F	Hip	Lung, pleura	Supportive care	0	9
[12]	44	M	Neck	Cervical spinal cord, para-aortic lymph nodes, lungs, kidney and liver	S + RT	36	36 +
[13]	30	M	Infratemporal fossa	Local recurrence	S + RT	12	12 +
[14]	42	F	Subcutaneous mass in sacrococcygeal area	Local recurrence and lymph node	S	8	52
[15]	43	F	Sciatic nerve	Local recurrence, lung	S	24	38
[16]	52	M	Lower lip	Local recurrence, lymph node, lung	S + RT	24	78
[17]	56	F	Anterior chest wall mass	Breast, lymph node	S	8	8 +
[18]	46	F	Breast	Lymph nodes, lungs, liver, and bone	S	?	108 +
[19]	60	M	Lower limb	?	S	?	12 +
[20]	69	M	Thigh	?	S	?	3
[21]	33	F	Vulva	Lymph nodes	S	6	6 +
[22]	60	M	Lumbosacral	Lymph nodes, lungs	S	?	36 +
[23]	?	?	Chest wall	Lymph node	S	0	0 +
[24]	33	F	Buttock	Local recurrence	S + RT	10	58 +
[25]	44	F	Tongue	Tongue, trachea, lung, and mediastinum	S	120	120 +
[26]	40	M	Buttock	Local recurrence, lymph node, lungs	S	16	87
[27]	51	F	Subungual tissue of finger	Local recurrence, multiple cutaneous nodules	S + CT + RT	24	42
[28]	41	M	Scapula, subcutaneous tissue	Local recurrence	S	24	24 +
[28]	52	M	Pelvis, deep soft tissue	Local recurrence	S	17	17 +
[29]	18	M	Anal canal	Local recurrence, inguinal lymph nodes	S + RT	10	24 +
[30]	48	F	Urinary Bladder	Local recurrence	S	4	40 +
[31]	30	F	Bilateral Breast	Right groin	S	36	36 +
[31]	36	F	Breast	Vulva	S	36	36 +
[32]	21	F	Cutaneous nodule	Local Recurrences	S	4	11 +
[33]	32	F	Vulva	Lymph nodes, Lungs	S	?	91
[34]	17	F	Vulva	Lymph nodes	S	?	35 +
Current report	43	F	Larynx	Lung, Bone	S +RT + CT	24	48 +
	Median	F/M				Median	Median
	42
	(17 – 72)	35/18				17	84

S: Surgery; RT: Radiotherapy; CT: Chemotherapy; F: Female; M: Male.

Figure 1.  Overall survival of metastatic granular cell tumor patients after metastases.

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