Hormone therapy and estrogen receptor expression in breast cancer

Figures & data

Table I.  Reproductive characteristics and BMI in HRT users and non-users (mean±SD).

	HRT user	HRT nonusers	Unknown	p-value	p adj for age
Age (years)	56±4.3 n = 128	58±4.4 n = 193		<0.001
Time since menopaus (months)	82±58 n = 89	106±64 n = 166	n = 66	0.004	0.347
BMI	24.7±3.8 n = 109	25.4±4.4 n = 160	n = 52	0.2	0.651
Nulliparous /parous	21/105 n = 127	33/159 n = 192	n = 2	0.98	0.552

Table II.  Tumor characteristics in HRT users and non-users expressed as rate (%).

	HRT users	HRT non-users	Unknown	p-value	p adj for age
Histology
Ductal	87/118 (74%)	130/179 (73%)	n = 24	0.98
Lobular	18/118 (15%)	28/179 (16%)
Other	3/118 (3%)	4/179 (2%)
DCIS	10/118 (8%)	17/179 (9%)
Tumor size
(mm)	20±15 n = 117	19±12 n = 177	n = 27	0.56	0.864
Positive nodes
0	85/119 (71%)	114/168 (68%)	n = 34	0.51	0.206
1–3	26/119 (22%)	36/168 (21%)
4–	8/119 (7%)	18/168 (11%)
ER positive	87/110 (79%)	134/168 (80%)	n = 100	0.99	0.959
PR positive	76/108 (70%)	96/153 (63%)	n = 176	0.25	0.729
ER value
fmol/µg DNA	1.17±1.5 n = 90	1.70±2.1 n = 135	n = 96	0.045	0.837
PR value
fmol/µg DNA	1.55±2.4 n = 92	1.6±2.9 n = 133	n = 96	0.85	0.996
Multifocal tumor	6/121 (5%)	22/177 (12%)	n = 23	0.049	0.852
Metastasis at diagn.	2/127 (2%)	10/192 (5%)	n = 2	0.17	0.145
Stage
0	10/125 (8%)	17/190 (9%)	n = 5	0.4	0.4
1	62/125 (50%)	85/190 (45%)
2	48/125 (38%)	77/190 (40%)
3	3/125 (2%)	2/190 (1%)
4	2/125 (2%)	10/190 (5%)

Table III.  Tumor characteristics in women on different HRT regimens (mean ± SD or rate (%)).

	Estrogen only	Continouos combined estrogen/progestogen	Cyclic estrogen/progestogen	Unknown	p-value	p adj for age
Tumor size
mm	23±18 n = 33	16±8 n = 47	23±19 n = 34	14	0.051	0.042
Positive nodes	1.0±2.2 n = 34	0.6±1.3 n = 48	1.0±2.6 n = 34	12	0.64	0.518
0	25/34 (73%)	33/48 (69%)	25/34 (73%)
1–3	6/34 (18%)	13/48 (27%)	6/34 (18%)
4	3/34 (9%)	2/48 (4%)	3/34 (9%)
ER
fmol/µg DNA	1.1±1.1 n = 29	1.3±1.8 n = 36	1.3±1.6 n = 23	40	0.79	0.795
PR
fmol/µg DNA	2.3±3.4 n = 28	1.6±2.1 n = 38	0.8±1.4 n = 24	38	0.1	0.108