Radiological and functional assessment of radiation-induced pulmonary damage following breast irradiation

Figures & data

Figure 1.  Follow-up (upper) and pre-irradiation (lower) CT images for patient with dense (Grade 3) radiographic appearances.

Figure 2.  Distribution of Forced Vital Capacity (FVC, % of expected).

Figure 3.  Fibrosis grade and Forced Vital Capacity (FVC, % of expected).

Figure 4.  Observed data (fraction of patients) and corresponding best fit (Table II) NTCP for a fibrosis score above 0 and above 1.

Table I.  e_rms for the response data (fraction of patients) vs. NTCP calculated using the m=0.34 and TD₅₀=28.8 Gy [4].

Endpoint	erms (n=0.5)	erms (n=0.87)
Score > 1	0.251	0.345
Score > 0	0.664	0.747
FVC < 80 %	0.068	0.093
FVC < 100 %	0.426	0.493

Table II.  Parameters with 95% confidence intervals and corresponding e_rms for the response data (fraction of patients) vs. calculated NTCP for n=0.5.

Endpoint	m	TD50	erms
Score > 1	0.37±0.18	19.6±1.6	0.039
Score > 0	0.41±0.91	13.0±6.6	0.117

Moiseenko V, Craig T, Bezjak A, Van Dyk J. Dose-volume analysis of lung complications in the radiation treatment of malignant thymoma: A retrospective review. Radiother Oncol 2003; 67: 265–74

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