Different etiological role of Helicobacter pylori (Hp) infection in carcinogenesis between differentiated and undifferentiated gastric cancers: A nested case-control study using IgG titer against Hp surface antigen

Figures & data

Table I.  Baseline characteristics of case and control subjects.

		Differentiated		Undifferentiated
		case n = 242	control n = 242	case n = 108	control n = 108
age	mean (SD)	57.5 (7.1)**^2)	57.5 (7.1)	54.3 (6.6)	54.3 (6.7)
Sex	men/women	186/56**^2)	186/56	51/57	51/57
Pepsinogen I (PGI)	mean (SD)	22.8 (14.5)**^2)	27.9 (18.5)	33.2 (18.8)	30.0(14.5)
Pepsinogen II (PGII)	mean (SD)	11.5 (6.9)**^2)	11.2 (7.0)	14.7 (7.3)	10.7 (5.8)
Ratio of PGI to PGII	median (IQR)	1.9 (1.5)*^2)	2.5 (2.2)	2.2 (1.1)	3.0 (1.8)
Hp IgG titer
entire period^1)	median (IQR)	36.0 (31.0)**^2)	34.1 (47.9)	46.2 (33.5)	39.2 (46.5)
< 7 years^1)	median (IQR)	34.7 (32.6)	30.7 (48.0)	37.7 (35.7)	33.4 (46.1)
> = 7 years^1)	median (IQR)	38.5 (34.1)*^2)	38.5 (48.0)	51.1 (39.1)	48.3 (51.1)

SD = standard deviation IQR= intraqurtail range.

¹⁾period between on-set and blood donation.

²⁾compared to undifferentiated cases **p < 0.01, *p < 0.05.

Table II.  Spearman's correlation coefficient between IgG titer and Pepsinogens.

	Differentiated		Undifferentiated
	case n = 242	control n = 242	case n = 108	control n = 108
Pepsinogen I (PGI)	0.20** (0.07, 0.32)	0.16 *(0.03, 0.28)	0.35 **(0.19–0.50)	0.29** (0.11, 0.47)
Pepsinogen II (PGII)	0.26**(0.15, 0.38)	0.61**(0.53, 0.70)	0.38** (0.22–0.55)	0.69** (0.58, 0.80)
Ratio of PGI to PGII	−0.002 (−0.14, 0.13)	−0.48**(−0.59, −0.37)	0.02 (−0.17–0.21)	−0.61** (−0.75, −0.47)
PGI and PGII^1)	0.64** (0.56, 0.73)	0.60**(0.52, 0.68)	0.79**(0.72–0.87)	0.66** (0.54, 0.77)

( ):95%confidence interval.

1) Spearman's correlation coefficient between PGI and PGII.

*P < 0.05, **p < 0.01.

Table III.  Odds ratios (ORs) for association of noncardia gastric cancer.

		Differentiated					Undifferentiated
period of on-set	Hp titer	case	control	OR	95%CI		case	control	OR	95%CI
Entire period	negative	17	63	reference			4	26	reference
	low	92	56	5.9	3.0	11.6	30	22	6.4	2.1	19.6
	middle	73	59	4.4	2.2	8.5	33	29	5.9	1.9	18.5
	high	60	64	3.2	1.6	6.4	41	31	7.8	2.4	24.9
		p for trend among positive cases < 0.05					5]p for trend among positive cases = 0.706
<7 year
	negative	13	43	reference			2	18	reference
	low	56	35	5.8	2.5	13.6	21	13	9.2	2.0	41.9
	middle	47	38	3.9	1.8	8.7	20	18	7.8	1.6	38.2
	high	34	34	3.2	1.3	7.7	21	15	11.6	2.3	59.1
		p for trend among positive cases = 0.395					p for trend among positive cases = 0.811
> = 7year
	negative	4	20	reference			2	8	reference
	low	36	21	6.5	2.0	20.5	9	9	3.5	0.6	20.5
	middle	26	21	5.7	1.7	19.7	13	11	3.9	0.7	20.4
	high	26	30	3.4	1.1	11.0	20	16	4.5	0.8	23.4
		p for trend among positive cases <0.05					]p for trend among positive cases = 0.758