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Original Article

Prognostic significance of numeric aberrations of genes for thymidylate synthase, thymidine phosphorylase and dihydrofolate reductase in colorectal cancer

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Pages 1054-1061 | Received 06 Dec 2007, Published online: 08 Jul 2009

Figures & data

Table I.  Distribution of thymidylate synthase (TYMS), thymidine phosphorylase (TP) and dihydrofolate reductase (DHFR) allele/nucleus according to clinical and pathological characteristics in 314 colorectal cancer patients.

Figure 1.  Distribution of thymidylate synthase expression score (0–3) assessed by immunohistochemistry according to number of TYMS allele/nucleus in colorectal cancer cells (n = 302).

Figure 1.  Distribution of thymidylate synthase expression score (0–3) assessed by immunohistochemistry according to number of TYMS allele/nucleus in colorectal cancer cells (n = 302).

Table II.  Univariate analyses of outcome according to TYMS, TP and DHFR allele/nucleus and disease stage in 314 colorectal cancer patients adjuvantly treated with 5-FU.

Figure 2.  Recurrence free survival following adjuvant chemotherapy of colorectal cancer stage II–IV by number of allele/nucleus for thymidylate synthase (A), thymidine phosphorylase (B) and dihydrofolate reductase (C) in tumor cells. Censored data are indicated (+).

Figure 2.  Recurrence free survival following adjuvant chemotherapy of colorectal cancer stage II–IV by number of allele/nucleus for thymidylate synthase (A), thymidine phosphorylase (B) and dihydrofolate reductase (C) in tumor cells. Censored data are indicated (+).

Table III.  Multivariate analysis of outcome according to allele/nucleus of TYMS, TP, and DHFR adjusted for the independent prognostic variables stage, vascular tumor invasion and bowel obstruction.

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