Incidence and survival of gastric non-Hodgkin's lymphoma: A population-based study from the Association of the French Cancer Registries (FRANCIM)

Figures & data

Table I.  Definitions of grades (codes from the International Classification of Diseases for Oncology, second edition) and corresponding number of cases included in the survival study (1989–1997).

Grade	ICDO-2 codes	N
High-grade	9673/3: lymphocytic, intermediate differentiation, diffuse	4
	9674/3 : centrocytic	7
	9676/3 : centroblastic-centrocytic, diffuse	5
	9680/3 : large cell, diffuse NOS	82
	9681/3 : large cell, cleaved, diffuse	1
	9682/3 : large cell, non cleaved, diffuse	6
	9683/3 : centroblastic diffuse	34
	9684/3 : immunoblastic	17
	9687/3 : Burkitt's lymphoma, NOS	1
	9697/3 : centroblastic, follicular	3
	9698/3 : large cell follicular, NOS	2
	9702/3 : peripheral T-cell lymphoma NOS	1
	9714/3 : large cell (K-1 + ) lymphoma	1
Total		164
Low-grade	9670/3 : small lymphocytic, NOS	35
	9671/3 : lymphoplasmacytic	13
	9672/3 : small cleaved cell, diffuse	3
	9675/3 : mixed small and large cell diffuse	17
	9686/3 : small cell, noncleaved, diffuse	1
	9690/3 : follicular, NOS	2
	9691/3 : mixed small cleaved and large cell, follicular	4
	9692/3 : centroblastic-centrocytic, follicular	2
	9693/3 : lymphocytic, well differentiated, nodular	1
	9695/3 : small cleaved cell, follicular	2
Total		80
Not Otherwise Specified (NOS)	9590/3 : malignant lymphoma NOS	98
	9591/3 : malignant lymphoma, non Hodgkin's, NOS	18
	9592/3 : lymphosarcoma NOS	1
Total		117
Total		361

Figure 1.  Age-standardized incidence rates per 100 000 in men and women from 1978–1982 to 1998–2002.

Table II.  Evolution of lymphoma grade distribution during the three study periods.

Grade	[1989–1991]	[1992–1994]	[1995–1997]
Low-grade GL (n = 80)	22%	29%	17%
NOS grade GL (n = 117)	41%	31%	27%
High-grade GL (n = 164)	37%	40%	57%

Table III.  Survival study population: Number of cases by sex, age and grade of malignancy.

Variable	Modality	Number of cases	Relative frequency (%)
Sex	Male	200	55.40%
	Female	161	44.60%
Age	[15; 45]	34	9.40%
	[45; 55]	41	11.40%
	[55; 65]	72	19.90%
	[65; 75]	88	24.40%
	[75; + + ]	126	34.90%
Grade of malignancy	Low-grade	80	22.20%
	High-grade	164	45.40%
	NOS	117	32.40%

Figure 2.  Curve of relative survival by sex for gastric non-Hodgkin's lymphoma diagnosed between January 1, 1989 and December 31, 1997.

Table IV.  Crude and relative survival at 1, 3 and 5 years. Relative survival by grade and by period of diagnosis (% and 95% Confidence Interval).

Survival	1 year	3 years	5 years
Crude survival	65 [60–70]	55 [50–60]	50 [45–55]
Relative survival	69 [64–74]	63 [57–68]	61 [55–66]
High-grade	67 [59–73]	61 [52–68]	58 [49–65]
Low-grade	74 [63–83]	69 [57–78]	68 [55–78]
NOS grade	66 [57–74]	62 [52–71]	62 [52–71]
[1989; 1991]	65 [55–73]	58 [48–68]	58 [46–67]
[1992; 1994]	70 [61–78]	61 [51–70]	59 [48–68]
[1995; 1997]	75 [65–82]	72 [62–80]	68 [56–77]

NOS: Not Otherwise Specified.

Figure 3.  Curve of relative survival by age for gastric non-Hodgkin's lymphoma diagnosed between January 1, 1989 and December 31, 1997.

Table V.  Multivariate analysis: Effect of covariates on the excess mortality rate (sex, age at diagnosis, year of diagnosis and grade) and 95% confidence interval (CI).

Covariates	Hazard ratio	95% CI lower limit	95% CI higher limit	P
Sex	1.04	0.73	1.50	0.815
Age at diagnosis	1.05	1.04	1.07	<0.001
Year of diagnosis	0.98	0.91	1.05	0.507
High-grade	0.78	0.78	2.04	0.345
NOS* grade	0.63	0.63	1.78	0.823

*NOS: Not Otherwise Specified.

Sex reference: male.

Grade reference: low.

Age at diagnosis and year of diagnosis are considered as continuous variables.

Table VI.  Age Standardized incidence Rates (ASR) per 100 000 person-years in population based studies on gastric lymphomas.

Study [reference]	Country	Study period	Number of cases	ASR Male	ASR Female	Standard population
Gurney et al. [1]	England	1986–1993	650	0.29	0.20	World
Ullrich et al. [15]	Germany	1993–1996	94	0.51	0.38	World
D'Amore et al. [2]	Denmark	1983–1991	175	0.85	0.59	European
Our study	France	1988–1992	198	0.66	0.52	World
Our study	France	1993–1997	187	0.60	0.29	World

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