Figures & data
Table I. Numbers of patients by technique (or group). PTV1 is composed of prostate and seminal vesicles, PTV2 refers as the lymphatic nodes.
Table II. Characteristics of patient population (percent of ill patients in respect to total population, mean dose of ill and safe patients, and standard deviation in the mean doses).
Figure 1. Selection of best tolerance dose for an acute GI grade larger than 2 based on maximum AUROC value.
![Figure 1. Selection of best tolerance dose for an acute GI grade larger than 2 based on maximum AUROC value.](/cms/asset/1a0d80dd-5a91-4ad4-ac49-664e63b964aa/ionc_a_408024_f0001_b.gif)
Figure 3. Selection of EUD n parameter an acute GI grade larger than 2 based on maximum AUROC value.
![Figure 3. Selection of EUD n parameter an acute GI grade larger than 2 based on maximum AUROC value.](/cms/asset/5cfd6e06-4680-445b-bba6-c5dbd29e03d8/ionc_a_408024_f0003_b.gif)
Figure 4. Likelihood fitting of acute GI by Lyman's NTCP model and fixing n parameters equal to 0.09.
![Figure 4. Likelihood fitting of acute GI by Lyman's NTCP model and fixing n parameters equal to 0.09.](/cms/asset/d8dc0a53-0e99-4e62-9f6b-1262abdaff27/ionc_a_408024_f0004_b.gif)
Figure 5. Observed frequencies of patients suffering acute GI (grade larger than 2) by bin of EUD versus NTCP expected values.
![Figure 5. Observed frequencies of patients suffering acute GI (grade larger than 2) by bin of EUD versus NTCP expected values.](/cms/asset/16ab5f69-48f9-40ab-a69f-3d4b34bd0a00/ionc_a_408024_f0005_b.gif)
Figure 7. Selection of best tolerance dose for an acute GU grade larger than 2 based on maximum AUROC value.
![Figure 7. Selection of best tolerance dose for an acute GU grade larger than 2 based on maximum AUROC value.](/cms/asset/06255560-0c5d-44ef-bed4-af071f233aae/ionc_a_408024_f0007_b.gif)
Figure 9. Selection of EUD n parameter an acute GU grade larger than 2 based on maximum AUROC value.
![Figure 9. Selection of EUD n parameter an acute GU grade larger than 2 based on maximum AUROC value.](/cms/asset/86cd5179-6ab3-4193-ac4b-235205b637d1/ionc_a_408024_f0009_b.gif)
Figure 10. Likelihood fitting of acute GU by Lyman's NTCP model and fixing n parameters equal to 0.06.
![Figure 10. Likelihood fitting of acute GU by Lyman's NTCP model and fixing n parameters equal to 0.06.](/cms/asset/103e61ee-16ba-479d-8bd8-ec730f49376c/ionc_a_408024_f0010_b.gif)
Figure 11. Observed frequencies of patients suffering acute GU (grade larger than 2) by bin of EUD versus NTCP expected values.
![Figure 11. Observed frequencies of patients suffering acute GU (grade larger than 2) by bin of EUD versus NTCP expected values.](/cms/asset/92967853-dd60-4431-b008-1c39d6e96c97/ionc_a_408024_f0011_b.gif)
Table III. Summary of AUROC and parameter values by criterion and endpoint.
Table IV. Fitted LKB NTCP m and TD50 parameters by keeping n equal to 0.09 (Acute GI) and n equal to 0.06 (acute GU), their values obtained for the AUROC comparisons.