Abnormalities in hippocampal volume of glioma patients prior to radiotherapy

Figures & data

Figure 1. Example of hippocampal segmentations, obtained using Freesurfer. Left and right hippocampi are visualized as contours overlaid over the T1-weighted pre-contrast anatomic image (left) and surface renderings (right).

Table 1. Patient and control group characteristics.

	Patients [n = 31]	Controls [n = 34]
Age
Mean [range], years	50 [19–70]	44 [19–70]
Gender
Male	24	18
Female	7	16
Seizures
Generalized tonic-clonic	7
Unspecified	5
Complex partial	1
None reported	18
Diagnosis^a
Glioblastoma (Grade IV)	19
Grade III	7
Grade II	5
Tumor hemisphere
Left	19
Right	11
Bilateral	1
Tumor neuroanatomical location
Frontal	12
Temporal	5
Fronto-parietal	4
Temporal-parietal	3
Occipital	3
Parietal	2
Cerebellum	1
Pons	1
Surgery
Subtotal resection	16
Gross total resection	14
Biopsy	1
Medication^b (drug Class)
Anticonvulsant	26
Glucocorticoid	23
5HT3 receptor antagonist	15
Narcotic analgesic	13
Antibiotics	13
Histamine-2 antagonist	11
Statin	10
Laxative	11
Proton pump inhibitor	9
Non-sulfonylureas	6

^a Grade III: anaplastic astrocytoma (3), anaplastic oligoastrocytoma (1), anaplastic ganglioglioma (1), anaplastic oligodendroglioma (1), glioneuronal (1). Grade II: astrocytoma (3), oligodendroglioma (1), oligoastrocytoma (1).

^b Medications with less than five patients are not listed.

Figure 2. Dot plots of normalized hippocampal volume (unitless) in controls, all patients, patients without (w/o) seizures and patients with (w) seizures. The red dots indicate the mean value of the group. Significant differences were found between all patients vs. controls, and patients with seizures vs. controls, but not between patients without seizures vs. controls, or patients with seizures vs. patients without seizures.