The ability of PAM50 risk of recurrence score to predict 10-year distant recurrence in hormone receptor-positive postmenopausal women with special histological subtypes

Figures & data

Table 1. Histological special subtypes and distribution of molecular intrinsic subtype including DR events and Deaths (any cause) (N = 89).

Histological subtypes	N = 89	Luminal A	Luminal B	HER2Enriched	Basallike	DR events	Deaths any cause
Apocrine	3	0	1	2	0	1	1
Medullary	5	0	1	1	3	1	2
Mucinous	51	23	26	2	0	4	28
Papillary	12	2	8	2	0	1	5
Secretory	1	1	0	0	0	0	0
Tubular	16	16	0	0	0	0	5
Neuroendocrine	1	0	1	0	0	0	0

Table 2. Patient characteristics. Special subtypes (except for invasive lobular carcinoma) are not graded according to national guidelines [www.dbcg.dk].

	IDC (N = 1570)	(%)	Special subtypes (N = 89)	(%)	p
Number of positive lymph nodes					.0005
0	425	(27%)	42	(47%)
1	636	(40%)	30	(34%)
2	324	(21%)	11	(12%)
3	185	(12%)	6	(7%)
Tumor size (mm)					.0002
≤10	100	(6%)	6	(7%)
11–20	560	(36%)	16	(18%)
21–30	680	(43%)	41	(46%)
>30	230	(15%)	26	(29%)
Grade
1	562	(36%)	6	(7%)
2	790	(50%)	4	(4%)
3	218	(14%)	0	(0%)
Not done	0	(0%)	79	(89%)
Lymphovascular invasion					.10
Present	221	(14%)	7	(8%)
Absent	1349	(86%)	82	(92%)
ER expression level					.54
10–59%	161	(10%)	6	(7%)
60–89%	335	(21%)	17	(19%)
90–99%	415	(27%)	27	(30%)
100%	638	(41%)	39	(44%)
Positive^a	21	(1%)	0	(0%)
Molecular subtype					^b.052
Luminal A	863	(55%)	42	(47%)
Luminal B	620	(39%)	37	(42%)
HER2Enriched	73	(5%)	7	(8%)
Basallike	14	(1%)	3	(3%)
ROR group
Low/intermediate (≤40)	532	(34%)	29	(33%)
High (>40)	1038	(66%)	60	(67%)

^a ER ≥10% the exact percentage unknown;

^b Fisher´s Exact Test.

Figure 1. Continuous relationship between 10-year risk of distant recurrence and the continuous PAM50-Prosigna ROR score by IDC and special subtypes. The figure shows for continuous ROR score (stated on x-axis) the 10-year risk of distant recurrence in percent (stated on y-axis) for each of the two subgroups, modeled by the Fine-Gray subdistribution hazards model.

Figure 2. Cumulative incidence and overall survival according to ROR score low/intermediate versus high (A + C) and molecular subtype (B + D) for IDC and special types (black = ductal, red = special types).

Figure 3. ▪

Table 3. Hazard Ratio (HR) estimates from multivariate analyzes for distant recurrence and overall survival.

	IDC		Special subtypes
	HR (95% CI)	p	HR (95% CI)	p
Distant recurrence
ROR Cont	1.78 (1.49–2.13)	<.0001	2.83 (1.28–6.26)	.01
Overall survival
ROR Cont	1.32 (1.21–1.45)	<.0001	1.11(0.79–1.55)	.56
Subtype
Luminal B vs	1.76 (1.41–2.21)	<.0001	1.23 (0.58–2.63)	.64
Luminal A