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ORIGINAL ARTICLES: BREAST CANCER

Expression of survivin does not appear to influence breast cancer recurrence risk

ORCID Icon, , , , , , , , , , & show all
Pages 154-161 | Received 23 Mar 2018, Accepted 16 Jul 2018, Published online: 23 Oct 2018

Figures & data

Figure 1. Selection of study sample and groupings based on inclusion criteria of subject in the population-based case-control study of women age 35–69, diagnosed with Stage I–III breast cancer between 1985–2001, and registered with the Danish Breast Cancer Group (n = 1682).

Figure 1. Selection of study sample and groupings based on inclusion criteria of subject in the population-based case-control study of women age 35–69, diagnosed with Stage I–III breast cancer between 1985–2001, and registered with the Danish Breast Cancer Group (n = 1682).

Figure 2. Immunohistochemical analysis of nuclear and cytoplasmic survivin expression. (A) IHC ×10 high cytoplasmic staining intensity, magnified to (B) IHC ×40, 60% high intensity, 40% low intensity. (C) IHC ×10 low/medium nuclear staining intensity, magnified to (D) IHC ×40, 5% medium intensity, 3% low intensity.

Figure 2. Immunohistochemical analysis of nuclear and cytoplasmic survivin expression. (A) IHC ×10 high cytoplasmic staining intensity, magnified to (B) IHC ×40, 60% high intensity, 40% low intensity. (C) IHC ×10 low/medium nuclear staining intensity, magnified to (D) IHC ×40, 5% medium intensity, 3% low intensity.

Table 1. Distribution of tumor and patient characteristics among breast cancer recurrence cases and controls by ER/TAM group among 1682 subjects in the population-based case-control study of women age 35–69, diagnosed with Stage I – III breast cancer between 1985 and 2001, and registered with the Danish Breast Cancer Group.

Table 2. Association between nuclear and cytoplasmic survivin and breast cancer recurrence from a population-based case-control study of 1312 women age 35–69, diagnosed with Stage I – III breast cancer between 1985 and 2001, and registered with the Danish Breast Cancer Group.

Table 3. Dose-response evaluation of the association between nuclear and cytoplasmic survivin and breast cancer recurrence from a population-based case-control study of 1312 women age 35–69, diagnosed with Stage I – III breast cancer between 1985 and 2001, and registered with the Danish Breast Cancer Group.

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