Breast cancer survival trends in different stages and age groups – a population-based study 1989–2013

Figures & data

Table 1. Number of patients per stage and percent per stage at indicated time periods.

	Stage (%)
Year of diagnosis	I	II N0	II N+	III	IV	Unknown	Total
1989–1993	2831 (42)	1586 (24)	1102 (16)	983 (15)	224 (3)	428	7154
1994–1998	3164 (44)	1663 (23)	1098 (15)	1014 (14)	200 (3)	537	7676
1999–2003	3531 (44)	1859 (23)	1363 (17)	1173 (14)	185 (2)	601	8712
2004–2008	3825 (44)	1790 (21)	1691 (19)	1179 (14)	223 (3)	344	9052
2009–2013	4132 (45)	1925 (21)	1718 (19)	1120 (12)	260 (3)	471	9626
Total	17483 (44)	8823 (22)	6972 (18)	5469 (14)	1092 (3)	2381	42220

Table 2. Number of patients per stage and percent per stage in indicated age groups.

	Stage (%)
Age	I	II N0	II N+	III	IV	Unknown	Total
<40	442 (29)	337 (22)	358 (23)	368 (24)	39 (3)	85	1629
40–54	4553 (44)	1982 (19)	2035 (20)	1607 (15)	196 (2)	554	10927
55–69	7950 (52)	2590 (17)	2597 (17)	1708 (11)	330 (2)	718	15893
70–89	4538 (36)	3914 (31)	1982 (16)	1786 (14)	527 (4)	1024	13771
Total	17483 (44)	8823 (22)	6972 (18)	5469 (14)	1092 (3)	2381	42220

Figure 1. Survival of breast cancer patients diagnosed 1989–2013 with different stages of the disease.

Table 3. Survival at indicated years for patients diagnosed 1989–2013 with different stages of the disease.

Stage	Endpoint (years)	Survival% (95 % CI)
I	5	97.8 (97.4–98.4)
	10	94.3 (93.5–95.2)
	15	91.2 (89.9–92.5)
	20	88.2 (86.1–90.2)
IIN0	5	87.4 (86.3–88.5)
	10	77.5 (75.8–79.1)
	15	72.4 (70.2–74.6)
	20	65.0 (61.8–68.2)
IIN+	5	89.5 (88.4–90.5)
	10	79.8 (78.2–81.3)
	15	71.6 (69.4–73.8)
	20	65.3 (62.1–68.4)
III	5	64.1 (62.6–65.6)
	10	46.8 (45.0–48.6)
	15	38.1 (36.0–40.3)
	20	33.2 (30.5–35.9)
IV	5	17.1 (14.6–19.8)
	10	8.7 (6.6–11.3)
	15	5.6 (3.4–8.6)
	20	3.6 (1.4–7.6)

Table 4. Five respectively ten-year excess mortality ratio (EMR) in the indicated stages and time periods.

Stage	Year of diagnosis	5-year EMR (95 % CI)	p value	10-year EMR (95 % CI)	p value
I	1989–1993	1.00		1.00
	1994–1998	1.37 (0.91–2.07)	.13	0.88 (0.66–1.18)	.40
	1999–2003	0.65 (0.40–1.08)	.10	0.72 (0.53–0.97)	.03
	2004–2008	0.59 (0.36–0.99)	.04	0.55 (0.39–0.78)	.001
	2009–2013	0.39 (0.16–0.92)	.03
II N0	1989–1993	1.00		1.00
	1994–1998	1.05 (0.81–1.34)	.72	1.01 (0.83–1.23)	.90
	1999–2003	0.78 (0.60–1.03)	.08	0.75 (0.60–0.92)	.006
	2004–2008	0.79 (0.61–1.04)	.09	0.70 (0.56–0.87)	.001
	2009–2013	0.80 (0.60–1.09)	.16
II N+	1989–1993	1.00		1.00
	1994–1998	0.83 (0.62–1.10)	.20	0.95 (0.77–1.18)	.001
	1999–2003	0.70 (0.53–0.93)	.02	0.68 (0.55–0.85)	<.001
	2004–2008	0.58 (0.43–0.77)	<.001	0.56 (0.44–0.70)	<.001
	2009–2013	0.44 (0.30–0.65)	<.001
III	1989–1993	1.00		1.00
	1994–1998	0.99 (0.86–1.15)	.92	0.96 (0.85–1.10)	.59
	1999–2003	0.75 (0.64–0.87)	<.001	0.74 (0.65–0.84)	<.001
	2004–2008	0.65 (0.56–0.77)	<.001	0.64 (0.56–0.73)	<.001
	2009–2013	0.52 (0.43–0.63)	<.001
IV	1989–1993	1.00
	1994–1998	0.98 (0.79–1.21)	.87
	1999–2003	0.91 (0.73–1.13)	.40
	2004–2008	0.83 (0.67–1.03)	.08
	2009–2013	0.69 (0.55–0.86)	.001
Total	1989–1993	1.00		1.00
	1994–1998	0.94 (0.85–1.03)	.19	0.90 (0.83–0.98)	.02
	1999–2003	0.69 (0.62–0.77)	<.001	0.69 (0.63–0.75)	<.001
	2004–2008	0.62 (0.56–0.69)	<.001	0.60 (0.55–0.66)	<.001
	2009–2013	0.51 (0.45–0.58)	<.001

Figure 2. Development of 5 and 10 years relative survival in patients with different stages of breast cancer, 1989–2013.

Figure 3. Development of 5 and 10 years relative survival in patients diagnosed 1989–2013 and stratified by age group.