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Original Articles

Increased serological, cancer-associated protein biomarker levels at diagnosis of large bowel adenoma: Risk of subsequent primary malignancy?

, , , , , , & show all
Pages S42-S48 | Received 16 Jul 2018, Accepted 28 Sep 2018, Published online: 07 Dec 2018

Figures & data

Table 1. Cancer location and time to primary malignancy.

Table 2. Primary colorectal examination.

Table 3. Subjects with elevated cancer-associated biomarkers.

Figure 1. Cumulative incidence of malignancy according to plasma/serum levels of A: CEA (p = .0008), B: TIMP-1 (p = .02), C: CA19-9 (p = .002) and D: YKL-40 (p = .002). The solid blue lines represent normal levels of the cancer-associated biomarkers with 95% CI. The dotted red lines represent elevated levels of the cancer-associated biomarkers with 95% CI.

Figure 1. Cumulative incidence of malignancy according to plasma/serum levels of A: CEA (p = .0008), B: TIMP-1 (p = .02), C: CA19-9 (p = .002) and D: YKL-40 (p = .002). The solid blue lines represent normal levels of the cancer-associated biomarkers with 95% CI. The dotted red lines represent elevated levels of the cancer-associated biomarkers with 95% CI.

Figure 2. Cumulative incidence of malignancy according to the multivariate analysis including the three defined groups (p = .0009). The solid blue line with 95% CI, represents group 0 with none of the four biomarkers elevated. The dotted red line with 95% CI, represents group 1, with one of the four biomarkers elevated. The dotted green line with 95% CI, represents group 2, with two or more of the four biomarkers elevated.

Figure 2. Cumulative incidence of malignancy according to the multivariate analysis including the three defined groups (p = .0009). The solid blue line with 95% CI, represents group 0 with none of the four biomarkers elevated. The dotted red line with 95% CI, represents group 1, with one of the four biomarkers elevated. The dotted green line with 95% CI, represents group 2, with two or more of the four biomarkers elevated.

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