Stereotactic irradiation of the resection cavity after surgical resection of brain metastases – when is the right timing?

Figures & data

Table 1. Patient characteristics in the treatment groups.

	Time between surgery and RT
	≤21 days	22–33 days	≥34 days	p Value
Mean age	66.5 ± 11.2	60.3 ± 13.1	58.0 ± 15.6	.094
Histologies
Breast cancer	8 (35%)	2 (10%)	1 (5%)
NSCLC	7 (30%)	7 (33%)	5 (23%)
GI tract	3 (13%)	5 (24%)	6 (27%)
Melanoma	2 (9%)	3 (14%)	5 (23%)
Other	3 (13%)	4 (19%)	5 (23%)	.213
Number of metastases
1	17 (74%)	18 (86%)	17 (77%)
2	5 (22%)	3 (14%)	5 (23%)
3	1 (4%)	0	0	.638
RPA class
1	3 (13%)	6 (29%)	4 (18%)
2	14 (61%)	15 (71%)	14 (64%)
3	4 (17%)	0	1 (5%)
unknown	2 (9%)	0	3 (14%)	.198
Recurrence/progression between surgery and RT
None	13 (56%)	15 (71%)	13 (59%)
Local	1 (4%)	2 (10%)	7 (32%)
Distant	0	2 (10%)	2 (9%)
Unknown	9 (39%)	2 (10%)	0	.160
Year of treatment
2009–2011	6 (26%)	4 (19%)	5 (23%)
2012–2014	6 (26%)	7 (33%)	15 (68%)
2015–2016	11 (48%)	10 (48%)	0 (9%)	.019*
Karnosfky performance Score
100–90	6 (26%)	10 (48%)	13 (59%)
80–70	12 (52%)	11 (52%)	5 (23%)
≤60	5 (22%)	0	1 (5%)
Unknown	0	0	3 (14%)	<.01*
Mean PTV (ml)	33.2 ± 16.4	23.1 ± 12.6	24.2 ± 13.2	.040*

^* Significant.

Figure 1. Overall survival depending on time interval between surgery and start of RT.

Figure 2. Local recurrence depending on time interval between surgery and start of RT.

Figure 3. Locoregional recurrence depending on time interval between surgery and start of RT.