Epithelioid sarcoma: half a century later

Figures & data

Table 1. (SEER) Demographic and clinicopathologic traits.

Total # of cases: 998
Mean age of diagnosis: 45.8 ± 21.5
	N	%		N	%
Age category^a			Anatomical region^a
Elderly (>80)	61	6.2	Upper limb	275	34.9
Old-adult (56–79)	272	27.5	Lower limb	193	24.5
Mid-adult (36–55)	312	31.6	Head and neck	51	6.5
Young-adult (18–35)	235	23.8	Abdomen	41	5.2
Pediatric (<18)	108	10.9	Trunk	36	4.6
Gender^a			Thorax	55	7
Male	546	55.3	Pelvis	138	17.5
Female	442	44.7	Unknown	209	–
Race^a			Grade^a
White	795	79.6	I–II	62	13.7
Black	117	11.8	III	194	42.7
Other	86	8.6	IV	198	43.6
Year of diagnosis: grouping #1^a			T-staging^a
Pre-2000	217	22	T1 (<5 cm)	191	49.5
Post-2000	771	78	T2, T3, T4 (>5 cm)	195	50.5
Year of diagnosis: grouping #2^a			N-staging^a
1973–2005	458	46.4	N0	375	64.2
2006–2015	530	53.6	N1 + N2	209	35.8
Treatment			M-staging^a
S–/R–	196	19.8	M0	381	77.6
S+/R–	458	46.4
S+/R+	287	29	M1	110	22.4
S–/R+	12	1.2
Unknown	35	3.5

^a Unknown values excluded from respective % contribution.

Table 2. (SEER) Traits – univariate cox regression and Kaplan-Meier analysis.

Cox regression hazard ratio analysis		Kaplan-Meier survival analysis
	HR	1-Year DSS %	5-Year DSS %	10-Year DSS %
Age category^a
Elderly (>80)	Ref.	38.3	14.3	–
Old-adult (56–79)	0.52	55.1	37.3	36.4
Mid-adult (36–55)	0.27	76.9	58.9	52.4
Young-adult (18–35)	0.24	86.9	64.8	52.5
Pediatric (<18)	0.13	89.1	77.1	72.7
Year of diagnosis: grouping #1^a
Pre-2000	Ref.	83.9	65.7	59
Post-2000	1.54	70.9	52.5	46
Year of diagnosis: grouping #2^a
1973–2005	Ref.	76.6	60	53.3
2006–2015	1.29	71.5	50.6	44.6
Grade^a
I-II	Ref.	96	91.6	73.4
III	4.43	65.1	45.3	42
IV	5.32	56.9	38.7	33.4
T-staging^a
T1	Ref.	94.8	84.2	83
T2	1.54	64	36	29
T3-T4	12.33	22.2	–	–
N-staging^a
N0	Ref.	83.3	65	59.8
N1	2.72	53.5	31.2	25.7
M-staging^a
M0	Ref.	87.4	67.6	61.4
M1	5.98	33	9.7	5.8
Anatomical region^a
Abdomen	Ref.	49.7	25.2	–
Lower limb	0.32	83.5	61.2	57.1
Upper limb	0.21	93.1	77.2	66.5
Trunk	0.26	78.1	71	66.6
Pelvis	0.41	75.9	56	47.7
Treatment^a
S–/R–	Ref.	31.1	8.5	5.7
S+/R–	0.14	85.4	71	64.3
S+/R+	0.18	86.8	63.8	54.7

^a Variables without significance excluded from table.

Table 3. (SEER) Traits – multivariate cox regression hazard ratio analysis.

Cox regression hazard ratio analysis
	HR	p Value
Age category^a
Mid-adult (36–55)	Ref.
Elderly (>80)	3.31	<.001
Old-adult (56–79)	1.89	<.001
Young-adult (18–35)	0.80	>.05
Pediatric (<18)	1.12	>.05
Year of diagnosis: grouping #1^a
Pre-2000	Ref.
Post-2000	1.55	.006
Grade^a
I-II	Ref.
III	4.34	<.001
IV	4.28	<.001
T-staging
T1 (<5 cm)	Ref.
T2 (>5 cm)	2.75	<.001
M-staging (at diagnosis)^a
M0	Ref.
M1	2.32	<.001
Anatomical region^a
Abdomen (proximal)	Ref.
Lower limb (distal)	0.51	.01
Upper limb (distal)	0.45	.003
Treatment^a
S–/R–	Ref.
S+/R–	0.23	<.001
S+/R+	0.27	<.001

^a Variables without significance excluded from table (except for age category).

Values that are bolded indicate possession of statistical significance.

Table 4. Pre- and post-2000 rates comparison – SEER and the literature combined.^a,b

	5 Year survival rate	10 Year survival rate	Recurrence rate	Metastasis rate
Prior to 1/1/2000 (cumulative)
Rate n/(SD)	67.7 628/5.50	59.1 349/10.89	68.2 338/17.7	44.9 360/2.05
After 1/1/2000 (cumulative)
Rate n/(SD)	56.5 1253/19.97	47.2 1152/22.01	56.9 248/21.4	33.8 253/11.9
Significance p value	Yes p < .0001	Yes p < .0001	Yes p < .0001	Yes p < .0001

^a Rates weighted by respective n counts per article/database.

^b Overall pre- and post-2000 values compared by combining cases from SEER and the literature.

Table 5. Overall SEER and literature rates.^a

	5 Year survival	10 Year survival	Recurrence rate	Metastasis rate
Prior to 1/1/2000 (literature)
Rate	68.8	59.2	68.2	44.9
n (# of ES cases)	n = 441	n = 132	n = 338	n = 360
n (# of articles)	n = 6	n = 3	n = 4	n = 5
After 1/1/2000 (literature)
Rate	63.0	49.5	56.9	33.8
n (# of ES cases)	n = 482	n = 381	n = 248	n = 253
n (# of articles)	n = 15	n = 12	n = 9	n = 8
SEER database
Rate	55.7	49.3	–	–
n (# of ES cases)	n = 998	n = 998
Overall
Rate	60.4	50.2	63.4	40.3
n (# of ES cases)	n = 1891	n = 1511	n = 586	n = 613

^a Separate literature (pre-2000 and post-2000), separate SEER, and overall (SEER and literature combined) values presented.

Data availability statement

The data that support the findings of this study are available upon request in the Surveillance, Epidemiology, and End Results Program Database [https://seer.cancer.gov/data/].