Hypoxia and local tumour control in squamous cell carcinoma of the anus – a hypothesis-generating study

Figures & data

Figure 1. Results on hypoxia classification of squamous cell carcinoma of the anus (SCCA) tissues using a 15-gene hypoxia classifier. A: Comparison between the mean expression level of each of the 15 genes between the SCCA samples on the x-axis and a representative head and neck squamous cell carcinoma (HNSCC) cohort on the y-axis. B: The sum scores for the 15 genes. A negative score categorises the tumour as less hypoxic, and a positive score categorises the tumour as more hypoxic. Each bar represents a case. For patients with local recurrence, the number of months from the end of treatment to the time for diagnosis of recurrence and tumour characteristics are measured in the table. C: Aalen-Johansen estimated correlation between hypoxia classification and local tumour control.

Table 1. Pretreatment Characteristics.

		Hypoxia classification
Pretreatment characteristics	Total (%)	Less (%)	More (%)	p Value
n	79 (100)	53 (100)	26 (100)
Age (median) 62 years, Range 26-82				0.64
<62 years	40 (50)	28 (53)	12 (46)
>62 years	39 (50)	25 (47)	14 (54)
Gender				1.00
Female	59 (75)	40 (75)	19 (73)
Male	20 (25)	13 (25)	7 (27)
Performance status				0.35
0	57 (72)	35 (66)	22 (85)
1	18 (23)	14 (26)	4 (15)
2	3 (4)	3 (6)	0
3	1 (1)	1 (2)	0
P16 status				0.11
Negative	11 (14)	10 (19)	1 (4)
Positive	65 (82)	42 (79)	23 (88)
Unknown	3 (4)	1 (2)	2 (8)
T-stage				0.33
T1	17 (22)	13 (24)	4 (15)
T2	46 (58)	31 (58)	15 (58)
T3	6 (8)	2 (4)	4 (15)
T4	10 (13)	7 (13)	3 (12)
N-stage				0.39
N0	61 (77)	43 (81)	18 (69)
N1	12 (15)	6 (11)	6 (23)
N2	6 (8)	4 (8)	2 (8)
N3	0
M-Stage				1.00
M0	78 (99)	52 (98)	26 (100)
M1	1 (1)	1 (2)	0
Risk*				0.46
Low	51 (65)	36 (68)	15 (58)
High	28 (35)	17 (32)	11 (42)

TNM version 7.0. *Low risk (T1-2, N0), high risk (T3-4 and/or N+).

Data availability statement

Data not available due to legal restrictions.