When breast cancer comes to the ICU: outcomes and prognostic factors

Figures & data

Table 1. Patients’ characteristics.

Characteristics	n = 177 patients
Age (years)	65 [57–75]
Female gender	175 (98.9)
Comorbidities
Hypertension	64 (36.2)
Diabetes	21 (11.9)
Baseline performance status 3–4	33 (18.6)
Time from cancer diagnosis to ICU admission (years)	3 [1–9]
Hormone receptors and HER2 status (available for 143 patients)
Estrogen receptor or progesterone  receptor positive or both	113 (79.0)
HER2-positive	37 (25.9)
Triple-negative	18 (12.6)
Stage (available for 174 patients)
Localized	34 (19.5)
Advanced	18 (10.3)
Metastatic	122 (70.1)
Status (available for 174 patients)
Newly diagnosed	25 (14.4)
Partial response	43 (24.7)
Complete remission	30 (17.2)
In progression	76 (43.7)
Treatment within the last 3 months
Chemotherapy	77 (43.5)
Endocrine therapy	27 (15.3)
Targeted therapy	26 (14.7)
Radiotherapy	16 (9.0)
Surgery	10 (5.6)

Continuous variables are expressed as median (interquartile range) and categorical variables as counts (percentages).

Table 2. Intensive care unit characteristics and outcomes.

Characteristics	n = 177 patients
Patterns of ICU admission
Nonspecific complications	75 (42.4)
Infection	56 (31.6)
Thrombo-embolic events	6 (3.4)
Other	13 (7.3)
Specific-complications	47 (26.6)
Pleural effusion	10 (5.6)
Hypercalcemia	10 (5.6)
Neurological complication	5 (2.8)
Thrombotic microangiopathy	4 (2.3)
Adverse events	19 (10.7)
Drug-related adverse event	11 (6.2)
Procedural adverse event	8 (4.5)
SOFA score at ICU admission	5 [4-8]
Organ failure supports
Invasive mechanical ventilation	72 (40.7)
Noninvasive mechanical ventilation	23 (13.0)
Vasopressors/inotropes	57 (32.2)
Renal replacement therapy	26 (14.7)
Decision to forgo life-sustaining therapies	45 (25.4)
Length-of-stay in the ICU (days)	3 [1–6]
Outcomes
ICU-mortality	37 (20.9)
Hospital-mortality (available for 173 patients)	79 (45.7)
One-year mortality (available for 170 patients)	97 (57.1)
Antitumoral treatment after discharge (available for 84 out of 96 newly diagnosed or previously treated hospital-survivors)
Continuation	65 (77.4)
Discontinuation because non-indication	8 (9.5)
Discontinuation despite theoretical indication	11 (13.1)

Continuous variables are expressed as median (interquartile range) and categorical variables as counts (percentages).

Figure 1. Short-term and one-year survival status according to performance status. Twenty eight day mortality was assessed according to performance status 0–1–2 vs. 3–4. The landmark is set at the time of ICU admission. One-year mortality was assessed in ICU-survivors according to performance status 0–1–2 vs. 3–4. The landmark is set at the time of ICU discharge.

Data availability statement

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.