Unusual cases of sinonasal malignancies: a letter to the editor on HPV-positive sinonasal squamous cell carcinomas

Figures & data

Figure 1. PRISMA Flowchart.

Table 1. Study characteristics: inclusion period, source, and number of cases.

Authors (publication year, country)	Centre/data source(s)	Inclusion period	Cases, n^a	WA, male patients	HPV and OS	p16 as surrogate marker
Al-Qurayshi et al. 2020, USA [7]*	National Cancer Database	2004–2015	537	63.1%	Correlation, p = 0.002	-
Alos et al. 2009, Spain [20]	Department of Pathology and treated at the Hospital Clinic, University of Barcelona	1981–2006	60	75%	Correlation, p = 0.0364	Sensitivity= 100% Specificity = 100%
Bishop et al. 2013, USA [27]	The surgical pathology archives of The Johns Hopkins Hospital	1995–2011	161	Not specified	-	97% of the HPV + tumours exhibited high p16 expression
Cabal et al. 2020, Spain [8]	Otolaryngology, Hospital Universitario central de Asturias	1989–2017	74	81.87%	No statistical correlation, unknown p-value	-
Cheung et al. 2010, Hong Kong [26]	Department of Ear, Nose & Throat, Pamela Youde Nethersole Eastern Hospital, Hong Kong	1995–2006	5	Not specified	-	No correlation between HPV + and p16+, p = 0.848
Chowdhury et al. 2017, USA [9]	Department of Otolaryngology, University of Kansas Medical Centre	1990–2015	26	73%	Correlation, p < 0.005	-
Cohen et al. 2019, USA [10]	University of Miami Department of Otolaryngology	2011–2017	47	60%	Correlation, unknown p-value	Sensitivity = 90% Specificity = 67%
Doescher et al. 2015, Germany [11]	Not specified	1994–2013	44	75%	No statistical correlation, p = 0.3	-
Hongo et al. 2021, Japan [12]	Kyushu University, Kyushu Cancer Centre, Hamanomachi Hospital, and Yamaguchi Red Cross Hospital	2003–2019	131	69.5%	Correlation, p = 0.0089	-
Hongo et al. 2021, Japan [13]	Kyushu University, Kyushu Cancer Centre, Hamanomachi Hospital, and Yamaguchi Red Cross Hospital	2003–2019	146	69.9%	Correlation, p = 0.0277	Sensitivity = 100% Specificity = 92.6% Positive predictive value = 52.4%
Hu et al. 2020, China [14]	The Eye and Ear, Nose & Throat Hospital of Fudan University	2010–2017	114	73.7%	-	Three HPV + cases out of 18 p16+
Jiromaru et al. 2020, Japan [15]	Kyushu University or Kyushu Cancer Centre	2003–2016	101	69.3%	Correlation, p = 0.0037	-
Jo et al. 2009, USA [16]	Department of Pathology, University of Virginia, Charlottesville	Not specified	4	Not specified	-	Three HPV + cases out of two p16+ cases
Kim et al. 2020, Korea [17]	Catholic Medical Centre hospitals, Seoul St. Mary’s Hospital and Bucheon St. Mary’s Hospital	2011–2019	27	Not specified	-	Sensitivity= 100%
Kılıç et al. 2017, USA [1]*	National Cancer Database	2010–2014	770	64.9%	Correlation, p < 0.0001	-
Laco et al. 2015, Czech Republic [18]	The Fingerland Department of Pathology (University Hospital, Hradec Kralove, Czech Republic), Department of Pathology (General University Hospital, Prague, Czech Republic), and Department of Pathology (University Hospital, Olomouc, Czech Republic)	1995–2014	49	69.4%	No statistical correlation, p = 0.23	-
Larque et al. 2014, Spain [19]	Hospital Clinic, University of Barcelona, Villarroel, Barcelona, Spain	1985–2010	70	74.3%	Correlation, p = 0.028	-
Li et al. 2018, USA [20]*	National Cancer Database	2010–2014	Not specified	74%	No statistical correlation, unknown p-value	-
Markovic et al. 2020, USA [21]	The departmental database of Icahn School of Medicine at Mount Sinai, New York	2011–2018	32	65.6%	No statistical correlation, p = 0.17	-
Nishikawa et al. 2021, Japan [22]	Department of Head and Neck Surgery, Aichi Cancer Centre Hospital	2008–2019	90	77.7%	Correlation, unknown p-value	-
Oliver et al. 2020, USA [19]*	National Cancer Database	2010–2016	1418	64.7%	Correlation, p < 0.001	-
Svajdler et al. 2020, Czech Republic [23]	Louis Pasteur University Hospital in Košice, Slovakia and Faculty Hospital in Pilsen, Czech Republic and a large private pathology laboratory in Prešov, Slovakia	2002–2014	34	70.6%	No statistical correlation, p = 0.60	Sensitivity= 62.5% Specificity = 92.3%
Tendron et al. 2022, France [4]	Head and Neck Cancer Committee Database of Gustave Roussy Cancer Campus, Université Paris Saclay, Villejuif, France	1990–2020	59	62.7%	No statistical correlation, p = 0.06	No prognostic value of p16 expression was observed for OS
Yamashita et al. 2015, Japan [24]	Not specified	Not specified	16	87.5%	-	p16+ overexpression identified in one of the four HPV + cases

WA: weighted average; HPV: human papillomavirus; OS: overall survival.

^a Only sinonasal squamous cell carcinoma cases were included.

* Overlapping inclusion period from the National Cancer Database.

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Data availability statement

The participants of this study did not give written consent for their data to be shared publicly, so due to the sensitive nature of the research supporting data is not available.