Labor market affiliation of patients with myeloproliferative neoplasms: a population-based matched cohort study

Figures & data

Figure 1. Study population of patients with MPN and matched _nonMPN comparators.

Table 1. Characteristics of the study population at index date.

	ET	nonET	PV	nonPV	MF	nonMF	MPN-U	nonMPN-U
Total number, n	1,140	11,181	1,109	10,873	533	5,217	560	5,466
Age in years, n (%)
<40	67 (5.9)	682 (6.1)	24 (2.2)	239 (2.2)	9 (1.7)	90 (1.7)	11 (2.0)	109 (2.0)
40–50	137 (12.0)	1,368 (12.2)	88 (7.9)	884 (8.1)	17 (3.2)	180 (3.5)	50 (8.9)	470 (8.6)
51–69	444 (38.9)	4,318 (38.6)	453 (40.8)	4,477 (41.2)	168 (31.5)	1,675 (32.1)	189 (33.8)	1,873 (34.3)
≥70	492 (43.2)	4,813 (43.0)	544 (49.1)	5,273 (48.5)	339 (63.6)	3,272 (62.7)	310 (55.4)	3,014 (55.1)
Median (IQR)	67 (55–76)	67 (55–76)	69 (61–77)	69 (61–77)	73 (66–79)	73 (66–79)	72 (63–80)	71 (63–80)
Sex, n (%)
Female	689 (60.4)	6,746 (60.3)	552 (49.8)	5,439 (50.0)	223 (41.8)	2,168 (41.6)	291 (52.0)	2,847 (52.1)
Level of education, n (%)
Short	355 (31.1)	3,537 (31.6)	419 (37.8)	4,184 (38.5)	192 (36.0)	1,917 (36.7)	221 (39.5)	2,203 (40.3)
Medium	430 (37.7)	4,305 (38.5)	446 (40.2)	4,471 (41.1)	234 (43.9)	2,347 (45.0)	224 (40.0)	2,217 (40.6)
Long	319 (28.0)	3,159 (28.3)	203 (18.3)	2,001 (18.4)	84 (15.8)	831 (15.9)	99 (17.7)	974 (17.8)
Missing	36 (3.2)	180 (1.6)	41 (3.7)	217 (2.0)	23 (4.3)	122 (2.3)	16 (2.9)	72 (1.3)
CCI score^a, n (%)
0	713 (62.5)	8,425 (75.4)	668 (60.2)	7,958 (73.2)	301 (56.5)	3,544 (67.9)	324 (57.9)	3,923 71.8)
1	230 (20.2)	1,312 (11.7)	242 (21.8)	1,350 (12.4)	109 (20.5)	755 (14.5)	116 (20.7)	706 (12.9)
>1	197 (17.3)	1,444 (12.9)	199 (17.9)	1,565 (14.4)	123 (23.1)	918 (17.6)	120 (21.4)	837 (15.3)
Median follow-up, years (IQR)	3.6 (2.1−5.3)	3.7 (2.2−5.4)	3.6 (2.3−5.3)	3.6 (2.3−5.5)	2.8 (1.5−4.7)	3.9 (2.2−5.5)	2.8 (1.7−4.8)	3.6 (2.1−5.6)
Individuals who died during follow-up, n (%)	157 (13.8)	1,319 (11.8)	173 (15.6)	1,420 (13.1)	222 (41.7)	1,006 (19.3)	198 (35.4)	882 (16.1)

^aCharlson Comorbidity Index score, excluding non-melanoma skin cancer (ICD-10: C44).

ET: essential thrombocythemia; IQR: interquartile range; MF: myelofibrosis; MPN-U: unclassifiable myeloproliferative neoplasm; PV: polycythemia vera.

Figure 2. Labor market affiliation as proportions by week for each diagnosis group from two years before until two years after diagnosis.

Table 2. Labor market affiliation in proportions pre- and post-diagnosis (cross-sectional), stratified by diagnosis group.

		Week relative to index
		−104	−52	52	104
Cohort	Labor market affiliation, % (95% CI)
ET	Working	41.3 (38.5−4.2)	39.3 (36.5−42.1)	33.3 (30.6−36.1)	31.1 (28.5−33.8)
	Unemployed	2.6 (1.7−3.6)	2.1 (1.3−2.9)	1.9 (1.1−2.7)	2.4 (1.5−3.3)
	Retirement pension	47.8 (44.9−50.7)	50.1 (47.2−53.0)	53.2 (50.3−56.1)	52.3 (49.4−55.2)
	Disability pension	5.4 (4.0−6.7)	5.2 (3.9−6.5)	5.0 (3.7−6.3)	5.3 (4.0−6.6)
	Sickness benefit and other health-related benefits	2.9 (1.9−3.9)	3.3 (2.3−4.4)	5.2 (3.9−6.5)	4.6 (3.4−5.9)
	Died	–	–	1.3 (0.7−2.0)	3.7 (2.6−4.8)
	Emigrated	–	–	0	0.6 (0.2−1.1)
nonET	Working	41.1 (40.1−42.0)	38.8 (37.9−39.7)	35.5 (34.6−36.4)	34.3 (33.4−35.2)
	Unemployed	3.1 (2.7−3.4)	3.1 (2.8−3.4)	2.6 (2.3−2.9)	2.1 (1.8−2.4)
	Retirement pension	48.7 (47.7−49.6)	51.1 (50.1−52.0)	53.7 (52.7−54.6)	53.3 (52.4−54.2)
	Disability pension	4.9 (4.5−5.3)	4.4 (4.0−4.8)	3.8 (3.4−4.1)	3.5 (3.1−3.8)
	Sickness benefit and other health-related benefits	2.3 (2.0−2.6)	2.6 (2.3−2.9)	2.4 (2.1−2.7)	2.4 (2.1−2.6)
	Died	–	–	2.0 (1.7−2.2)	3.7 (3.4−4.1)
	Emigrated	–	–	0.1 (0.0−0.1)	0.7 (0.6−0.9)
PV	Working	31.0 (28.3−33.7)	28.9 (26.3−31.6)	22.7 (20.3−25.2)	21.5 (19.0−23.9)
	Unemployed	4.2 (3.1−5.4)	3.8 (2.7−4.9)	3.4 (2.4−4.5)	3.2 (2.1−4.2)
	Retirement pension	57.3 (54.3−60.2)	59.6 (56.7−62.5)	63.8 (60.9−66.6)	^a
	Disability pension	5.0 (3.8−6.3)	5.1 (3.8−6.4)	4.9 (3.6−6.1)	4.5 (3.3−5.7)
	Sickness benefit and other health-related benefits	2.4 (1.5−3.3)	2.5 (1.6−3.4)	4.1 (2.9−5.2)	3.8 (2.7−4.9)
	Died	–	–	1.2 (0.5−1.8)	3.2 (2.1−4.2)
	Emigrated	–	–	0	^a
nonPV	Working	34.3 (33.4−35.2)	32.5 (31.6−33.4)	28.8 (27.9−29.6)	26.9 (26.1−27.7)
	Unemployed	2.7 (2.4−3.0)	2.4 (2.1−2.6)	1.9 (1.6−2.1)	1.8 (1.6−2.1)
	Retirement pension	56.0 (55.0−56.9)	58.2 (57.2−59.1)	60.9 (60.0−61.8)	61.1 (60.1−62.0)
	Disability pension	5.0 (4.6−5.4)	4.9 (4.5−5.3)	4.2 (3.8−4.6)	3.9 (3.5−4.3)
	Sickness benefit and other health-related benefits	2.0 (1.8−2.3)	2.1 (1.8−2.3)	1.9 (1.7−2.2)	1.7 (1.4−1.9)
	Died	–	–	2.2 (2.0−2.5)	4.2 (3.8−4.6)
	Emigrated	–	–	0.1 (0.0−0.1)	0.5 (0.4−0.6)
MF	Working	28.1 (24.3−32.0)	26.3 (22.5−30.0)	20.1 (16.7−23.5)	20.1 (16.7−23.5)
	Unemployed	^a	1.5 (0.5−2.5)	^a	^a
	Retirement pension	64.5 (60.5−68.6)	^a	^a	53.3 (49.0−57.5)
	Disability pension	5.4 (3.5−7.4)	4.9 (3.0−6.7)	3.8 (2.1−5.4)	3.4 (1.8−4.9)
	Sickness benefit and other health-related benefits	^a	^a	3.9 (2.3−5.6)	2.1 (0.9−3.3)
	Died	–	–	10.7 (8.1−13.3)	19.7 (16.3−23.1)
	Emigrated	–	–	0	^a
nonMF	Working	26.4 (25.2−27.6)	24.9 (23.8−26.1)	22.2 (21.1−23.4)	20.6 (19.5−21.7)
	Unemployed	2.0 (1.6−2.3)	1.7 (1.4−2.1)	1.4 (1.1−1.7)	1.2 (0.9−1.5)
	Retirement pension	66.4 (65.1−67.6)	68.5 (67.2−69.8)	^a	68.3 (67.0−69.5)
	Disability pension	3.9 (3.3−4.4)	3.4 (2.9−3.9)	2.6 (2.2−3.0)	2.1 (1.7−2.5)
	Sickness benefit and other health-related benefits	1.4 (1.1−1.7)	1.5 (1.1−1.8)	1.3 (1.0−1.6)	1.2 (0.9−1.5)
	Died	–	–	2.7 (2.2−3.1)	5.5 (4.8−6.1)
	Emigrated	–	–	^a	1.1 (0.8−1.4)
MPN-U	Working	28.2 (24.5−31.9)	25.7 (22.1−29.3)	19.8 (16.5−23.1)	20.2 (16.9−23.5)
	Unemployed	2.3 (1.1−3.6)	3.0 (1.6−4.5)	3.0 (1.6−4.5)	1.8 (0.7−2.9)
	Retirement pension	61.8 (57.8–65.8)	63.8 (59.8−67.7)	61.4 (57.4−65.5)	^a
	Disability pension	5.2 (3.3−7.0)	5.4 (3.5−7.2)	4.5 (2.8−6.2)	3.8 (2.2−5.3)
	Sickness benefit and other health-related benefits	2.5 (1.2−3.8)	2.1 (0.9−3.3)	3.6 (2.0−5.1)	2.5 (1.2−3.8)
	Died	–	–	7.7 (5.5−9.9)	13.4 (10.6−16.2)
	Emigrated	–	–	0	^a
nonMPN-U	Working	32.0 (30.7−33.2)	29.3 (28.1−30.6)	26.2 (25.1−27.4)	24.6 (23.4−25.7)
	Unemployed	1.8 (1.4−2.1)	2.0 (1.6−2.4)	1.5 (1.2−1.8)	1.3 (1.0−1.6)
	Retirement pension	60.4 (59.1−61.7)	62.6 (61.3−63.9)	^a	64.4 (63.1−65.7)
	Disability pension	3.9 (3.4−4.4)	3.9 (3.4−4.4)	3.3 (2.8−3.8)	2.9 (2.5−3.4)
	Sickness benefit and other health-related benefits	1.9 (1.6−2.3)	2.2 (1.8−2.6)	1.8 (1.4−2.1)	1.8 (1.4−2.1)
	Died	–	–	2.3 (1.9−2.7)	4.6 (4.1−5.2)
	Emigrated	–	–	^a	0.4 (0.2−0.5)

^aPercentages based on exact cell counts below or equal to five and related cell counts were omitted to prevent identification of individuals by cross-tabulation.

CI: confidence interval; ET: essential thrombocythemia; MF: myelofibrosis; MPN-U: unclassifiable myeloproliferative neoplasm; PV: polycythemia vera.

Table 3. Labor market affiliation in proportions at index week (cross-sectional), stratified by diagnosis group.

	ET	nonET	PV	nonPV	MF	nonMF	MPN-U	nonMPN-U
Labor market affiliation, % (95% CI)
Working	35.3 (32.5−38.0)	37.2 (36.3−38.1)	22.5 (20.1−25.0)	30.6 (29.8−31.5)	22.9 (19.3−26.5)	23.6 (22.4−24.7)	21.6 (18.2−25.0)	27.8 (26.6−29.0)
Unemployed	2.3 (1.4−3.1)	2.7 (2.4−3.0)	3.2 (2.2−4.3)	2.4 (2.1−2.7)	^a	1.4 (1.1−1.8)	2.3 (1.1−3.6)	1.6 (1.3−2.0)
Retirement pension	52.1 (49.2−55.0)	53.3 (52.4−54.2)	62.3 (59.5−65.2)	60.4 (59.5−61.3)	68.9 (64.9−72.8)	70.5 (69.2−71.7)	66.8 (62.9−70.7)	64.9 (63.7−66.2)
Disability pension	5.1 (3.8−6.4)	4.1 (3.7−4.5)	4.9 (3.6−6.1)	4.7 (4.3−5.1)	4.1 (2.4−5.8)	3.1 (2.6−3.6)	4.6 (2.9−6.4)	3.7 (3.2−4.2)
Sickness benefit	3.6 (2.5−4.7)	1.4 (1.2−1.6)	5.5 (4.2−6.8)	0.9 (0.7−1.0)	3.2 (1.7−4.7)	0.7 (0.4−0.9)	3.4 (1.9−4.9)	1.1 (0.8−1.4)
Other health-related benefits	1.7 (0.9−2.4)	1.3 (1.1−1.5)	1.5 (0.8−2.3)	1.0 (0.8- 1.2)	^a	0.8 (0.6−1.0)	1.3 (0.3−2.2)	0.9 (0.6−1.1)

^aPercentages based on exact cell counts below or equal to five and related cell counts were omitted to prevent identification of individuals by cross-tabulation.

CI: confidence interval; ET: essential thrombocythemia; MF: myelofibrosis; MPN-U: unclassifiable myeloproliferative neoplasm; PV: polycythemia vera.

Data availability statement

Data presented in this study were obtained from Danish registries and handled remotely at secured servers at Statistics Denmark. Owing to the guidelines by Statistics Denmark, the authors are not allowed to share individual-level data. Anonymized data (including counts reported as '≤5' persons) are shared in the manuscript. Other researchers who fulfil the requirements set by the data providers could obtain similar data.