Evaluating the dosimetric effect of intra-fractional variations in deep inspiration breath-hold radiotherapy – a proof-of-concept study

Figures & data

Figure 1. Primary tumor position of the four patients, for which the suggested method was tested (top row images) and summary of lesion and PTV characteristics (below). PTV margins were population based [10], however, individually modified for patient #1 due to large tumor deviation between DIBHs.

Figure 2. Workflow for the intra-fractional robustness evaluation of DIBH RT.

Figure 3. Dosimetric comparison of the original plan (x-axis) and the simulated sum dose (y-axis), representing an estimate of the dosimetric effect of anatomical differences between consecutive DIBHs. The shaded areas represent the values where planning constraints for OARs are not met. Each patient is represented by his/her own symbol. If planning constraints are met in the original plan, but not in the simulated sum dose, symbols are marked as red. Note that patient #4 has a T-site lesion only and is therefore not presented on the PTV-N plot.

Josipovic M, Persson GF, Dueck J, et al. Geometric uncertainties in voluntary deep inspiration breath hold radiotherapy for locally advanced lung cancer. Radiother Oncol. 2016;118(3):510–514. doi: 10.1016/j.radonc.2015.11.004.

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Data availability statement

Data not available due to ethical/legal restrictions.