Adherence to thyroid hormone replacement therapy: a retrospective, claims database analysis

Figures & data

Figure 1. Study flowchart. The biggest loss in patients was due to the eligibility requirement, with approximately 85% of individuals not having 12 months of continuous enrollment. Abbreviations. M, million; Pts, patients; Tx, treatment; HT, hypothyroidism; Dx, diagnosis; THR, thyroid hormone replacement.

Table 1. Patient demographics and clinical characteristics at baseline.

	Patient sample (n = 580,331)
Age, years, mean (SE)	52.11 (0.02)
Female gender, n (%)	429,075 (73.94)
Charlson Comorbidity Score, n (%)
0	208,203 (35.88)
1	177,296 (30.55)
2	78,055 (13.45)
3	47,427 (8.17)
4+	69,350 (11.95)
Insurance, n (%)
Health Maintenance Organization	87,167 (15.02)
Preferred Provider Organization	292,148 (50.34)
Comprehensive	102,138 (17.60)
Other	90,862 (15.66)
Unknown	8,016 (1.38)
Region, n (%)
North Central	143,941 (24.80)
Northeast	65,425 (11.27)
South	225,037 (38.78)
West	102,183 (17.61)
Unknown	43,745 (7.54)
Year of Index Date
2000–2005	115,343 (19.88%)
2006–2010	209,117 (36.03%)
2011–2016	255,871 (44.09%)
Index drug, n (%)
Generic levothyroxine	394,209 (67.93)
Levoxyl^®	38,412 (6.62)
Synthroid^®	145,396 (25.05)
Tirosint^®	862 (0.15)
Unithroid^®	1,452 (0.25)

Figure 2. Proportion of patients adherent (≥80% PDC) at 6 and 12 months.

Figure 3. Proportion of patient adherent (≥80% PDC) at 6 and 12 months by individual formulations of levothyroxine.

Figure 4. Odds of being adherent (≥80% PDC) at 12 months compared to generic levothyroxine. Results from multivariable logistic regressions which control for patient age, sex, region, insurance, index year, and Charlson Comorbidity Score. Abbreviations. OR, odds ratio; CI, confidence interval.

Data availability

The data that support the findings of this study are available from Truven Health Analytics. Restrictions apply to the availability of these data, which were used under license for this study. Data are available from the authors with the permission of Truven. Copyright © 2018 Truven Health Analytics LLC. All Rights Reserved.