Mortality, length of stay and costs associated with acute graft-versus-host disease during hospitalization for allogeneic hematopoietic stem cell transplantation

Figures & data

Table 1. Demographics and clinical characteristics of allo-HSCT admissions in patients with and without aGVHD.

Characteristic	aGVHD	No GVHD	p value
	(n = 729)	(n = 5949)
Age
Median, years	40.0	50.0	<.01
≥18 years, n (%)	515 (70.6)	4976 (83.6)	<.01
<18 years, n (%)	214 (29.4)	973 (16.4)
Sex, n (%)			.40
Male	435 (59.7)	3455 (58.1)
Race, n (%)			.18
White	492 (67.5)	4058 (68.2)
Hispanic	88 (12.1)	613 (10.3)
Black	46 (6.3)	401 (6.7)
Asian or Pacific Islander	26 (3.6)	169 (2.8)
Other	20 (2.7)	246 (4.1)
Type of payer, n (%)			.17
Private (including HMO)	439 (60.2)	3737 (62.8)
Medicaid	158 (21.7)	905 (15.2)
Medicare	75 (10.3)	823 (13.8)
Other	57 (7.8)	453 (8.1)
Hospital region in the United States, n (%)			<.01
West	264 (36.2)	1180 (19.8)
South	201 (27.6)	1779 (29.9)
Northeast	133 (18.2)	1456 (24.5)
Midwest	131 (18.0)	1534 (25.8)
HSCT diagnosis, n (%)			.09
Leukemia	447 (61.3)	3425 (57.6)
Other malignancy	90 (12.4)	607 (10.2)
Non-Hodgkin lymphoma	70 (9.6)	688 (11.6)
Aplastic anemia	26 (3.6)	255 (4.3)
Other	96 (13.2)	974 (16.4)
Graft source, n (%)			<.01
Peripheral blood	501 (68.7)	4556 (76.6)
Bone marrow	119 (16.3)	977 (16.4)
Cord blood	105 (14.4)	362 (6.1)
Number of chronic comorbidities			<.01
Median	6.0	5.0
Comorbid conditions*, n (%)
Hypertension	268 (36.8)	2189 (36.7)	.99
Diabetes without chronic complications	102 (14.0)	600 (10.1)	.01
Depression	65 (8.9)	655 (11.0)	.09

Abbreviations. aGVHD, Acute graft-versus-host disease; allo-HSCT, Allogeneic hematopoietic stem cell transplantation; GVHD, Graft-versus-host disease; HMO, Health maintenance organization.

*Comorbidities may have originated prior to hospitalization for allo-HSCT.

Figure 1. Death during hospitalization for allo-HSCT. Abbreviations. aGVHD, Acute graft-versus-host disease; allo-HSCT, Allogeneic hematopoietic stem cell transplantation; GVHD, Graft-versus-host disease.

Figure 2. Median LOS during hospitalization for allo-HSCT. Error bars represent the IQR. Data missing for 1 patient in the non-GVHD group. Abbreviations. aGVHD, Acute graft-versus-host disease; allo-HSCT, Allogeneic hematopoietic stem cell transplantation; GVHD, Graft-versus-host disease; IQR, Interquartile range; LOS, Length of stay.

Figure 3. Median costs per stay during hospitalization for allo-HSCT. Error bars represent the IQR. Data missing for 1 patient in the non-GVHD group. Abbreviations. aGVHD, Acute graft-versus-host disease; allo-HSCT, Allogeneic hematopoietic stem cell transplantation; GVHD, Graft-versus-host disease; IQR, Interquartile range.