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Orthopedic medicine

Critical thinking about three meta-analyses: can vitamin D alone or with calcium prevent fractures?

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Pages 497-501 | Received 15 Jul 2019, Accepted 27 Oct 2019, Published online: 19 Nov 2019

Figures & data

Figure 1. A fracture results from the balance between fracture risk factors and fracture prevention measures.

Figure 1. A fracture results from the balance between fracture risk factors and fracture prevention measures.

Figure 2. Critical thinking about the studies on the supplementation (vitamin D, calcium) and the incidences of osteoporosis and fractures. Assuming no significantly differences in osteoporosis, low BMD, and fracture incidences between the two groups in baseline; Incidence rate in the Treatment group is significantly lower than that in the Control group. This Figure does not algorithmize the situation, in which the incidence rates of osteoporosis, low BMD, or fractures in the Treatment group is significantly higher than that in the control group; *No significant difference regarding the incidence rates between the treatment group and the control group; $Need Vit D/Ca supplementation for the prevention of osteoporosis, low BMD, and/or fractures. ¥The assumption is accepted here that if X is a risk factor for a condition Y, X significant decrease would result in Y significant decrease, and vice versa, assuming that all other factors are the same. Abbreviations: Ca, Calcium; Co, Control group; Tx, Treatment group; vit: Vitamin.

Figure 2. Critical thinking about the studies on the supplementation (vitamin D, calcium) and the incidences of osteoporosis and fractures. †Assuming no significantly differences in osteoporosis, low BMD, and fracture incidences between the two groups in baseline; ‡Incidence rate in the Treatment group is significantly lower than that in the Control group. This Figure does not algorithmize the situation, in which the incidence rates of osteoporosis, low BMD, or fractures in the Treatment group is significantly higher than that in the control group; *No significant difference regarding the incidence rates between the treatment group and the control group; $Need Vit D/Ca supplementation for the prevention of osteoporosis, low BMD, and/or fractures. ¥The assumption is accepted here that if X is a risk factor for a condition Y, X significant decrease would result in Y significant decrease, and vice versa, assuming that all other factors are the same. Abbreviations: Ca, Calcium; Co, Control group; Tx, Treatment group; vit: Vitamin.

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