Getting the levothyroxine (LT4) dose right for adults with hypothyroidism: opportunities and challenges in the use of modern LT4 preparations

Figures & data

Table 1. Tablet strengths of levothyroxine (LT4) available in the European Union.

LT4 dosage strength (µg)	Multiple^a	Multiple^b	Multiple^c	Accord^d	AbZ^e	Aristo^f	Aspen^g	IBSA^h	Lamda^i	Norpharm^j	Orion^k	Merck KGaA^l	Sanofi^m	Uni-Pharma^n
12.5				☑				☑^o						☑
25	☑^o	☑^o	☑^o	☑	☑	☑	☑	☑^o	☑^o		☑	☑	☑	☑
38												•
50	☑^o	☑^o	☑^o	☑	☑	☑	☑	☑^o	☑^o	☑^o	☑	☑	☑	☑
63												•	☑	☑^p
75		☑	☑	☑	☑		☑	☑^o			☑	☑	☑	☑
88		☑		☑			☑	☑^o				☑	☑	☑
100	☑^o	☑^o	☑^o	☑	☑	☑	☑	☑^o	☑^o	☑^o	☑	☑	☑	☑
112		☑		☑	☑		☑	☑^o				☑	☑	☑
125		☑	☑	☑	☑		☑	☑^o	☑^o		☑	☑	☑	☑
137		☑		☑			☑	☑^o				☑	☑	☑
150		☑	☑	☑	☑		☑	☑^o			☑	☑	☑	☑
175		☑	☑	☑	☑		☑	☑^o				☑	☑	☑
200		☑	☑	☑	☑	☑	☑	☑^o				☑	☑	☑

Formulations listed in the European Union/European economic Area Heads of Medicines website are shown (not all formulations may be available in all countries).²⁴ Sponsor names are abbreviated in the title and are listed in the source as follows: ^aGalenica SA, Helm AG, Istituto Biochimico Nazionale Savio Srl, JensonR+ (Ireland) Limited, Mercury Pharmaceuticals Limited, Wockhardt UK Limited; ^bRatiopharm GmbH, Tillomed Pharma GmbH; ^cZentiva Pharma GmbH or Zentiva ks, Abdi Farma Unipessoal Lda; ^dAccord Healthcare; ^eAbZ-Pharma GmbH; ^fAristo Pharma GmbH; ^gAspen Pharma Trading Limited; ^hIBSA Farmaceutici Italia; ^ILamda Laboratories SA; ^jNorpharm Regulatory Services; ^kOrion Corporation (Finland); ^lMerck KGaA or Merck Serono; ^mSanofi-Aventis Deutschland GmbH; ⁿUni-Pharma Kleon Tsetis Pharmaceuticals Laboratories SA. ^oTablets and/or liquid formulation; ^pactual strength 62 mg, included here for convenience. • denotes planned tablet strengths.

ClinCalc.com. Levothyroxine. Drug Usage Statistics, United States, 2013–2019; [cited 2022 Mar]. Available from: https://clincalc.com/DrugStats/Drugs/Levothyroxine.

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