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Infectious Diseases

Comorbidity and comedication burden among people living with HIV in the United States

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Pages 1443-1450 | Received 01 Nov 2021, Accepted 07 Jun 2022, Published online: 21 Jul 2022

Figures & data

Table 1. Demographic and clinical characteristics among PLWH and PLWoH.

Table 2. Comorbidity burden measures, PLWH vs. PLWoH.

Figure 1. Proportion of cohorts with selected comorbid conditions, PLWH vs. PLWoH. Abbreviations. GI, Gastrointestinal; PLWH, People living with HIV; PLWoH, People living without HIV. *These listed were the most prevalent or relevant of the 67 conditions selected among those in the Chronic Conditions Data Warehouse. Dyslipidemia (includes hyperlipidemia or lipid disorders); GI disorders (includes diarrhea, nausea/vomiting, peptic ulcer disease and esophageal reflux); and liver disease (includes cirrhosis, fatty liver disease and other conditions, except for viral hepatitis) represent several specific conditions. ϮWith the exception of obesity/overweight (p = 0.206) and ischemic heart disease (p = 0.539), all p < 0.001.

Figure 1. Proportion of cohorts with selected comorbid conditions, PLWH vs. PLWoH*Ϯ. Abbreviations. GI, Gastrointestinal; PLWH, People living with HIV; PLWoH, People living without HIV. *These listed were the most prevalent or relevant of the 67 conditions selected among those in the Chronic Conditions Data Warehouse. Dyslipidemia (includes hyperlipidemia or lipid disorders); GI disorders (includes diarrhea, nausea/vomiting, peptic ulcer disease and esophageal reflux); and liver disease (includes cirrhosis, fatty liver disease and other conditions, except for viral hepatitis) represent several specific conditions. ϮWith the exception of obesity/overweight (p = 0.206) and ischemic heart disease (p = 0.539), all p < 0.001.

Figure 2. Proportion of PLWH and PLWoH with selected comedications. *p < 0.001. Mood disorders include depression and anxiety. Abbreviations. PLWH, People living with HIV; PLWoH, People living without HIV; PPI, Proton pump inhibitor.

Figure 2. Proportion of PLWH and PLWoH with selected comedications. *p < 0.001. Mood disorders include depression and anxiety. Abbreviations. PLWH, People living with HIV; PLWoH, People living without HIV; PPI, Proton pump inhibitor.

Figure 3. Proportions of PLWH with 2+ comorbidities and ≥5 fills of non-ARV comedications*, 2014 to 2018. Trends with clustering p value for each measure <0.001. *Not including ARV medications. Abbreviations. NDC, National Drug Code.

Figure 3. Proportions of PLWH with 2+ comorbidities and ≥5 fills of non-ARV comedications*, 2014 to 2018. Trends with clustering p value for each measure <0.001. *Not including ARV medications. Abbreviations. NDC, National Drug Code.
Supplemental material

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Data availability statement

Data used to generate these results cannot be disclosed publicly. Proprietary data obtained from the Optum Research Database may be accessed only with strictest data security and privacy protocols, and oversight with a restrictive license agreement.

Results in part were presented at the 2021 Conference on Retroviruses and Opportunistic Infections Virtual Meeting, 6–10 February 2021; and ID Week 2021 Virtual Meeting, 29 September–3 October 2021.