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Respiratory Medicine

Over-prescription of short-acting β2-agonists is associated with poor asthma outcomes: results from the African cohort of the SABINA III study

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Pages 1983-1995 | Received 23 Dec 2021, Accepted 05 Jul 2022, Published online: 27 Aug 2022

Figures & data

Table 1. Demographics and baseline clinical characteristics of the SABINA III African population by investigator-classified asthma severity and practice type.

Table 2. Asthma characteristics of the SABINA III African population according to investigator-classified asthma severity and practice type.

Figure 1. Proportion of patients (%) receiving SABA prescriptions in the 12 months before the study visit according to investigator-classified asthma severity and practice type in the SABINA III African cohort (N = 1778): (A) all patients, (B) mild asthma, and (C) moderate-to-severe asthma. *Patients without SABA prescriptions did not report which reliever they were using. Abbreviations. SABA, short-acting β2-agonist; SABINA, SABA use IN asthma.

Figure 1. Proportion of patients (%) receiving SABA prescriptions in the 12 months before the study visit according to investigator-classified asthma severity and practice type in the SABINA III African cohort (N = 1778): (A) all patients, (B) mild asthma, and (C) moderate-to-severe asthma. *Patients without SABA prescriptions did not report which reliever they were using. Abbreviations. SABA, short-acting β2-agonist; SABINA, SABA use IN asthma.

Table 3. Asthma treatments prescribed and SABA canisters purchased OTC in the 12 months before the study visit by patients in the SABINA III African cohort.

Figure 2. Association of SABA prescriptions with (A) severe exacerbations in the 12 months before the study visit and (B) level of asthma control assessed during the study visit in the SABINA III African cohort. Abbreviations. BMI, body mass index; CI, confidence interval; GINA, global initiative for asthma; IRR, incidence rate ratio; OR, odds ratio; SABA, short-acting β2-agonist; SABINA, SABA use IN asthma. Based on the covariable significance in the models, IRRs are corrected by country, age, sex, BMI, tobacco smoking history, GINA step, healthcare insurance, prescriber type, comorbidity, asthma duration, and education level. ORs are corrected by country, age, sex, BMI, asthma duration, tobacco smoking history, comorbidity, GINA step, healthcare insurance, prescriber type, and education level.

Figure 2. Association of SABA prescriptions with (A) severe exacerbations in the 12 months before the study visit and (B) level of asthma control assessed during the study visit in the SABINA III African cohort. Abbreviations. BMI, body mass index; CI, confidence interval; GINA, global initiative for asthma; IRR, incidence rate ratio; OR, odds ratio; SABA, short-acting β2-agonist; SABINA, SABA use IN asthma. Based on the covariable significance in the models, IRRs are corrected by country, age, sex, BMI, tobacco smoking history, GINA step, healthcare insurance, prescriber type, comorbidity, asthma duration, and education level. ORs are corrected by country, age, sex, BMI, asthma duration, tobacco smoking history, comorbidity, GINA step, healthcare insurance, prescriber type, and education level.
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Data availability statement

Data underlying the findings described in this manuscript may be obtained in accordance with AstraZeneca’s data sharing policy described at https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure.