Observational study to characterize treatment-resistant depression in Germany, France and the United Kingdom: analysis of real-world data collected through a survey of healthcare professionals

Figures & data

Table 1. Baseline characteristics of patients with treatment-resistant depression, overall and across countries (N = 1125).

Variable/category	Overall N (%)	France N (%)	Germany N (%)	United Kingdom N (%)
Patient number	1125 (100.0)	375 (33.3)	375 (33.3)	375 (33.3)
Male sex	528 (46.9)	177 (47.2)	180 (48.0)	171 (45.6)
Age
18–29	175 (15.6)	48 (12.8)	59 (15.7)	68 (18.1)
30–39	241 (21.4)	87 (23.2)	72 (19.2)	82 (21.9)
40–49	253 (22.5)	85 (22.7)	73 (19.5)	95 (25.3)
50–59	251 (22.3)	85 (22.7)	87 (23.2)	79 (21.1)
60–69	157 (14.0)	52 (13.9)	62 (16.5)	43 (11.5)
70+	48 (4.3)	18 (4.8)	22 (5.9)	8 (2.1)
Number of previous MDD episodes
None	106 (9.4)	42 (11.2)	26 (6.9)	38 (10.1)
1	195 (17.3)	65 (17.3)	57 (15.2)	73 (19.5)
2	287 (25.5)	99 (26.4)	99 (26.4)	89 (23.7)
3	215 (19.1)	78 (20.8)	63 (16.8)	74 (19.7)
4	101 (9.0)	28 (7.5)	41 (10.9)	32 (8.5)
5+	221 (19.6)	63 (16.8)	89 (23.7)	69 (18.4)
Employment status
Employed	301 (26.8)	90 (24.0)	103 (27.4)	108 (28.8)
Sick leave/unemployed/disability	589 (52.3)	202 (53.9)	172 (45.9)	215 (57.4)
Retired	183 (16.3)	63 (16.8)	81 (21.6)	39 (10.4)
Student/in training	52 (4.6)	20 (5.3)	19 (5.1)	13 (3.5)
Number of previous treatments
2–4	613 (54.5)	187 (49.9)	215 (57.3)	211 (56.2)
5+	512 (45.5)	188 (50.1)	160 (42.7)	164 (43.8)
Top five psychiatric comorbidities for TRD^a
Suicidal ideation	521 (46.3)	188 (50.1)	186 (49.6)	147 (39.2)
Family history of depression	507 (45.1)	173 (46.1)	161 (42.9)	173 (46.1)
General anxiety disorder diagnosis	351 (31.2)	130 (34.7)	90 (24.0)	131 (34.9)
Insomnia diagnosis	326 (29.0)	125 (33.3)	106 (28.3)	95 (25.3)
Suicide attempts	279 (24.8)	108 (28.8)	76 (20.3)	95 (25.3)

Abbreviations. MDD, Major depressive disorder; TRD, Treatment-resistant depression.

a Multi-select was allowed for the variable, so the total percentage may be >100%.

Figure 1. Number of treatment lines and treatment patterns across the market among patients with treatment-resistant depression (N = 1125).

Figure 2. Distribution of current treatment regimen in the most recent/current treatment-resistant depression episode (N = 1125).

Figure 3. Employment status and healthcare resource utilization among patients with treatment-resistant depression (N = 1125).

Data availability statement

Raw data used to draw the conclusions of this study are available as a supplementary file.