Bioethics of somatic gene therapy: what do we know so far?

Figures & data

Figure 1. The PRISMA flow diagram of the study selection process.

Table 1. ID, authors and year of articles included in the cohort.

1= Traulsen et al. 2008	74= McKenny et al. 1999	147= Kimmelman 2003
2= Addison et al. 2017	75= Farrelly 2004	148= Pattee 2008
3= Thrasher et al. 2013	76= Cole-Turner 1997	149= Delhove et al. 2020
4= Barns et al. 2000	77= Fost 1993	150= Horst 2007
5= Carmen 2001	78= Churchill et al. 1998	151= Zallen 1996
6= Hughes 2019	79= Chadwick et al. 1998	152= Sato et al. 2006
7= Riva et al. 2019	80= Friedmann 2019	153= Kimmelman 2008
8= Steele 2000	81= Gustafson 1992	154= Kimmelman 2005
9= Bonatti et al. 2002	82= Lacadena 2005	155= Anderson 1991
10= Ledley 1995	83= Williams 2002	156= Areen 1985
11= Holtug 1997	84= Kaplan et al. 2000	157= Leavitt 2001
12= Baird 1994	85= Gage 1987	158= Black 1998
13= Kim et al. 2009	86= Costea et al. 2009	159= Cornetta et al. 2002
14= Podhajcer et al. 1998	87= Savulescu 2001	160= Cornetta 2003
15= Sturgis et al. 2005	88= Editorial 1993	161= Orkin et al. 1995
16= Kimmelman 2012	89= Health Department of the United Kingdom Gene Therapy Advisory Committee 2001	162= Committee 1992
17= Freire et al. 2014	90= Wirth et al. 2013	163= Priest 2009
18= Swazo 2006	91= Messer 1999	164= Ragni 2002
19= Walter 2003	92= McGleenan 1995	165= Temin 1990
20= Fischer 2000	93= Larson 1990	166= Lagay 1999
21= Pepper et al. 2018	94= Launis 2002	167= Lebo et al. 1991
22= Ledley 1991	95= Carmen 1993	168= Weatherall 1995
23= Friedmann 2004	96= Holtug 1993	169= Anderson 1990
24= Lowenstein 2008	97= Walters 1991	170= Nelles et al. 2015
25= Moseley 1991	98= Krimsky 1990	171= Motulsky 1989
26= King et al. 2005	99= Anderson 1985	172= Ledley 1987
27= Campbell et al. 1998	100= Leiden 2000	173= Ledley 1992
28= Tauer 1990	101= Anderson 1989	174= Kimmelman 2007
29= Scully 2001	102= Patel 1993	175= Lyngstadaas 2002
30= Kimmelman et al. 2005	103= Ellliot 1993	176= Kimmelman 2008
31= King et al. 2008	104= Kahn 2008	177= Glass et al. 1999
32= Nicholson et al. 1995	105= Zänker et al. 1997	178= Norfolk et al. 1990
33= Levin 2016	106= Macer et al. 1995	179= Bayertz et al. 1994
34= Flotte 2015	107= Richter et al. 1998	180= Xiang et al. 2015
35= Fletcher 1985	108= Editorial 1996	181= Risco 2006
36= Penticuff 1994	109= Fitzgerald 2002	182= Espin-Villacres et al. 2001
37= Shannon 1999	110= Ruiz-Perez 1993	183= Rodriguez Yunta 2003
38= Fost 1992	111= Casanova Perdomo 2011	184= Agudelo Vélez et al. 2013
39= Bernstein et al. 2004	112= Green 2005	185= Smith et al. 2010
40= Zhang 2008	113= Dickens 1996	186= Pace 2004
41= Haan 1990	114= Areen 1990	187= Ledley et al. 1992
42= Kimmelman 2012	115= Wilson 2009	188= Wilson 2010
43= Valenzuela 2003	116= Robin et al. 1987	189= Walters 1986
44= Fletcher 1990	117= Palmer 1991	190= Kimmelman 2008
45= Nevin 1998	118= Nunes et al. 1996	191= Dyer 1997
46= Kaji et al. 2001	119= Neel 1997	192= McDonough 1997
47= Goering 2000	120= Barreiro 1999	193= Bunch et al. 2000
48= Drugan et al. 1987	121= Baramt 2001	194= Friedmann 1990
49= Bertolaso et al. 2010	122= Crisp 1995	195= Farrelly 2004
50= Royal Commission on New Reproductive Technologies 1994	123= Gafo 2000	196= Nycum et al. 2007
51= Kaspar et al. 2009	124= Friedmann 2000	197= Fletcher 1998
52= Danks 1993	125= Swiss Academy of Medical Sciences 1999	198= Kraj 2002
53= Dimichele et al. 2003	126= Winter et al. 1995	199= Sadler et al. 2004
54= Giangrande 2004	127= Bruce 2006	200= Juengst 1990
55= Dimichele 2005	128= Stahl 2015	201= Kong 2004
56= Friedmann et al. 1972	129= Fletcher 1983	202= Karpati et al. 1997
57= Anderson et al. 1980	130= Turriff et al. 2019	203= Walter 1999
58= Hoshino 1995	131= Lenk et al. 2007	204= Henderson et al. 2006
59= Weatherall 1991	132= Ebbesen et al. 2006	205= Kimmelman et al. 2005
60= Ashcroft 2004	133= Scully et al. 2004	206= Kimmelman 2009
61= Robinson et al. 1996	134= Benjaminy et al. 2014	207= Gilbert 2008
62= Wolf et al. 2009	135= Miller 1995	208= Kass 2000
63= Spink et al. 2004	136= Cohen-Haguenauer 1995	209= Henderson et al. 2004
64= Roth et al. 2002	137= Steele 2000	210= Teichler Zallen 2000
65= Mavilio 2010	138= Brooks et al. 2019	211= Anderson 1992
66= Rabino 2003	139= Aiyegbusi et al. 2020	212= Robillard et al. 2013
67= Jin et al. 2008	140= Konduros 2019	213= Stockdale 1999
68= Cohen-Haguenauer 1997	141= King et al. 2010	214= Ponder et al. 2008
69= Hillman et al. 1996	142= Dettweiler et al. 2001	215= Chapman et al. 2019
70= Smith 2003	143= Gansbacher 2002	216= Porter 1990
71= Hoose 1990	144= Robillard et al. 2014	217= Keenan 1990
72= Fuchs 2006	145= Górecki 2001
73= Amor 2001	146= Shalala 2000

Note: For full cohort details, see S5 Appendix.

Figure 2. Categories grouped in research-related and society-related.