Figures & data
Figure 1. The dose-response characteristics of the PTr method run at room temperature on Simple Simon™ for dabigatran, apixaban, and rivaroxaban in comparison with Hemoclot dTT®, our in-house anti-FXa methods, measured on a plasma pool from five healthy donors spiked with the drugs with respective NOAC. The zero-point is without addition.
Figure 2. The dose-response characteristics of the PTr method run at room temperature on Simple Simon™ for dabigatran in comparison with Hemoclot dTT® (a), and apixaban (b) and rivaroxaban (c) in comparison with our in-house anti-FXa methods. Plasmas from patients on treatment with the respective NOAC were used (n = 30); only one plasma sample from each patient. The zero-point is healthy donors without treatment.
Figure 3. The dose-response characteristics of the PTr method run at +37 °C on ACL Top for dabigatran in comparison with Hemoclot™ dTT (a), and apixaban our in-house anti-FXa methods (b). Plasmas from patients on treatment with the respective NOAC were used. The zero-point is healthy donors without treatment. n = 12 in (a), n = 20 in (b).
Figure 4. The dose-response characteristics of the PT method run at room temperature on Simple Simon™ for apixaban and PT measured on ACL Top at 37 °C in comparison with our in-house anti-FXa method run at +37 °C on ACL Top. n = 20. The zero-point is healthy donors without treatment.
