Increased psoriasis frequency in patients with familial Mediterranean fever

Figures & data

Table 1. Demographic and clinical characteristics of 177 adult and 174 pediatric patients with familial Mediterranean fever (FMF).

Characteristics	Adult patients (n = 177)	Pediatric patients (n = 174)	p value
Gender, female, n (%)	124 (70.1)	93 (53.4)	0.001
Abdominal pain, n (%)	159 (89.8)	166 (95.4)	0.046
Fever, n (%)	152 (85.9)	170 (97.7)	<0.0001
Arthralgia, n (%)	147 (83.1)	76 (43.7)	<0.0001
Arthritis, n (%)	93 (52.5)	27 (15.5)	<0.0001
Pleuritic chest pain, n (%)	104 (58.8)	14 (8)	<0.0001
Pericarditis, n (%)	7 (4)	0 (0)	0.007
Amyloidosis, n (%)	5 (2.8)	1 (0.6)	0.215
Family history of FMF, n (%)	99 (55.9)	94 (54)	0.719
Parental consanguinity, n (%)	44 (25)	25 (14.4)	0.012
Hemodialysis history in family associated with FMF, n (%)	20 (11.3)	11 (6.3)	0.132
Psoriasis, n (%)	11 (6.2)	2 (1.1)	0.020
Psoriasis in any degree relatives, n (%)	22 (12.4)	9 (5.2)	0.023
Psoriasis in first-degree relatives, n (%)	5 (2.8)	2 (1.1)	0.44
Psoriasis in second-degree relatives, n (%)	5 (2.8)	6 (3.4)	0.73
Psoriasis in third-degree relatives, n (%)	15 (8.5)	1 (0.6)	<0.0001
Improvement of psoriasis lesions with colchicine treatment, n (%)	5 (45.5)	0 (0)	0.48

FMF: familial Mediterranean fever.

Table 2. Comparing demographic and clinical characteristics of familial Mediterranean fever (FMF) patients with or without psoriasis.

Characteristics	Patients with psoriasis (n = 13)	Patients without psoriasis (n = 338)	p value
Gender, female, n (%)	9 (69.2)	208 (61.5)	0.5
Abdominal pain, n (%)	12 (92.3)	313 (92.6)	0.9
Fever, n (%)	12 (92.3)	310 (91.7)	0.9
Arthralgia, n (%)	12 (92.3)	211 (62.4)	0.028
Arthritis, n (%)	8 (61.5)	112 (33.1)	0.034
Pleuritic chest pain, n (%)	8 (61.5)	110 (32.5)	0.03
Pericarditis, n (%)	2 (15.4)	5 (1.5)	0.025
Amyloidosis, n (%)	1 (7.7)	5 (1.5)	0.204
Family history of FMF, n (%)	7 (53.8)	186 (55)	0.93
Parental consanguinity, n (%)	1 (7.7)	68 (20.2)	0.47
Hemodialysis history in family associated with FMF, n (%)	1 (7.7)	30 (8.9)	0.88

FMF: familial Mediterranean fever.

Table 3. The MEFV variants in familial Mediterranean fever (FMF) patients with and without psoriasis.

MEFV variants	FMF patients without psoriasis (n = 338) n (%)	FMF patients with psoriasis (n = 13) n (%)
M694V/M694V	104 (30.7)	3 (23.0)
M694V/-	43 (12.7)	3 (23.0)
M694V/M680I	32 (9.4)	1 (7.6)
M694V/V726A	24 (7.1)	0 (0)
M680I/M680I	17 (5.0)	1 (7.6)
M694V/E148Q	13 (3.8)	0 (0)
M680I/-	10 (2.9)	0 (0)
V726A/-	9 (2.6)	1 (7.6)
M680I/V726A	7 (2.0)	0 (0)
E148Q/-	7 (2.0)	1 (7.6)
M694V/R761H	5 (1.4)	0 (0)
E148Q/E148Q	4 (1.1)	0 (0)
M694V/M694I	1 (0.2)	1 (7.6)
E148Q/P369S	2 (0.5)	0 (0)
M680I/E148Q	1 (0.2)	0 (0)
M680I/R761H	1 (0.2)	0 (0)
V726A/E148Q	1 (0.2)	0 (0)
V726A/F479L	1 (0.2)	0 (0)
V726A/P369S	1 (0.2)	0 (0)
E148Q/R761H	1 (0.2)	0 (0)
P369S/P369S	1 (0.2)	0 (0)
P369S/-	1 (0.2)	0 (0)
R761H/-	1 (0.2)	0 (0)
A744S/-	1 (0.2)	0 (0)
F479L/-	1 (0.2)	0 (0)
-/-	15 (4.4)	0 (0)
MEFV analysis absent	34 (10.0)	2 (15.3)

MEFV: Mediterranean fever; FMF: familial Mediterranean fever.