Determination of topramezone and M670H05 in maize and animal samples by ultra-high-performance liquid chromatography-tandem mass spectrometry

ABSTRACT

A sensitive extraction and instrumental method was established to detect topramezone and its metabolite (M670H05) in maize and animal-origin foods. Two years of field experiments were carried out to study the dissipation dynamics of topramezone in maize straw, and their residue levels of actual samples collected from the supermarket were determined. They were extracted using liquid–liquid extraction (LLE), and ultra-high-performance liquid chromatography–tandem mass spectrometry was used for detection. The limit of quantification was 0.005 mg kg⁻¹. Recoveries ranged between 73.8% and 109.9% at 3 spiking levels with intraday relative standard deviation (RSD) ≤17.7% and the inter-day ≤18.1%, which meets the requirements of SANTE/12682/2019. Dissipation dynamics experiment showed that, the deposition of topramezone in maize straw in Jilin were <0.005–0.62 mg kg⁻¹with 28 days after application. And the residue level of market samples were all less than 0.005 mg kg⁻¹, much lower than the MRLs (range from 0.01 to 0.8 mg kg⁻¹) set by European Union, United States Food and Drug Administration, China, and Canada. This method was effective to analyse the residues of topramezone and M670H05.

KEYWORDS:

• Topramezone
• dissipation dynamics
• liquid–liquid extraction
• final residue
• metabolite

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by the National Natural Science Foundation of China [31672057].