Comparison of iron chelators used alone or in combination with phlebotomy in common mynahs (Acridotheres tristis) with experimental iron storage disease

Figures & data

Figure 1. Comparison of the liver iron following different treatments. DFP: deferiprone; DFP + F: deferiprone and phlebotomy; DFO: deferoxamine; DFO + F: deferoxamine and phlebotomy. † Significant difference between treatments and post-iron loading time (P < 0.05), ‡ Significant difference between treatments and both pre- and post-iron loading times (P < 0.05), * Significant difference between the first and second month of treatments (P < 0.05). No significant differences present among treatments.

Figure 2. Comparison of the liver zinc following different treatments. DFP: deferiprone; DFP + F: deferiprone and phlebotomy; DFO: deferoxamine; DFO + F: deferoxamine and phlebotomy. † Significant difference between treatments and post-iron loading time (P < 0.05), * Significant difference between the first and second month of treatments (P< 0.05). No significant differences present among treatments.

Figure 3. Comparison of the liver copper following different treatments. DFP: deferiprone; DFP + F: deferiprone and phlebotomy; DFO: deferoxamine; DFO + F: deferoxamine and phlebotomy. ‡ Significant difference between treatments and pre-iron loading time (P < 0.05), * Significant difference between the first and second month of treatments (P < 0.05). No significant differences present among treatments.

Table 1. Comparison of the body weights (mean ± SE) following different treatments.

Time	Treatment
	DFP (n = 7)	DFP + F (n = 7)	DFO (n = 7)	DFO + F (n = 7)
Pre-iron load	116 ± 6^a	115 ± 4^a	120 ± 4^a	129 ± 5^a
Post-iron load	78 ± 4^b	86 ± 6^b	87 ± 4^b	81 ± 4^b
1 month treatment	113 ± 5^a	113 ± 7^ab	103 ± 7^ab	103 ± 5^abc
2 months' treatment	115 ± 6^a	123 ± 7^a	106 ± 6^a	107 ± 6^c

DFP: deferiprone; DFP + F: deferiprone and phlebotomy; DFO: deferoxamine; DFO + F: deferoxamine and phlebotomy. Different letters indicate a significant time effect within each treatment (P < 0.05). No significant differences present among treatments.