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Experimental Aging Research
An International Journal Devoted to the Scientific Study of the Aging Process
Volume 49, 2023 - Issue 1
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Research Article

Aerobic Training and Circulating Neurotrophins in Alzheimer’s Disease Patients: A Controlled Trial

Angelica Miki Steina The Human Performance Research Group, UTFPR: Universidade Tecnológica Federal do Paraná, Curitiba,PRBRAZIL;b Postgraduate Program in Physical Education, UFTM: Universidade Federal do Triangulo Mineiro, Uberaba, Brazil;c Instituto Federal do Triângulo Mineiro, Patos de Minas, MG, BrazilCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-2404-808XView further author information
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Flávia Gomes de Melo Coelhoc Instituto Federal do Triângulo Mineiro, Patos de Minas, MG, Brazil;d Department of Pharmacology, Biomedical Sciences Institute, USP: Universidade de Sao Paulo, São Paulo, BrazilORCID Iconhttps://orcid.org/0000-0003-1838-1959View further author information
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Thays Martins Vital-Silvac Instituto Federal do Triângulo Mineiro, Patos de Minas, MG, Brazil;e Institute of Biosciences, UNESP: Universidade Estadual Paulista Julio de Mesquita Filho, Rio Claro, SP, BrazilORCID Iconhttps://orcid.org/0000-0002-9523-1156View further author information
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André Veloso Ruedaf Institute of Psychiatry, UFRJ: Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, BrazilORCID Iconhttps://orcid.org/0000-0003-4581-8992View further author information
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Jessica Rodrigues Pereirac Instituto Federal do Triângulo Mineiro, Patos de Minas, MG, BrazilORCID Iconhttps://orcid.org/0000-0003-3040-5562View further author information
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Andréa Camaz Deslandesg Center of Mathematics, Computing and Cognition, UFABC: Universidade Federal do ABC, São Paulo, SP, BrazilORCID Iconhttps://orcid.org/0000-0001-5941-9111View further author information
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Rosana Camarinif Institute of Psychiatry, UFRJ: Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, BrazilORCID Iconhttps://orcid.org/0000-0002-8131-6108View further author information
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Ruth Ferreira Santos Galdurózc Instituto Federal do Triângulo Mineiro, Patos de Minas, MG, Brazil;h Ufabc: Universidade Federal Do Abc, Santo André/SPBrazilORCID Iconhttps://orcid.org/0000-0002-0778-1087View further author information
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Pages 1-17 | Received 18 Apr 2021, Accepted 28 Feb 2022, Published online: 06 Mar 2022
 
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ABSTRACT

Objective

to verify the effects of aerobic exercise training in circulating BDNF, VEGF165 and IGF-1 plasma levels and cognitive function in Alzheimer’s Disease (AD) patients.

Methods

34 AD patients participated in the study, divided in two groups: Control Group (CG; n = 16) and Training Group (TG; n = 18 – Moderate aerobic training on the treadmill, three times a week, for 12 weeks). BDNF, VEGF165, and IGF-1 plasma levels were considered as a primary outcome. Secondary outcomes included cognitive functions and aerobic fitness.

Results

After 12 weeks, maintenance of executive functioning in the TG was found, yet no significant changes on circulating neurotrophins levels were identified. For aerobic fitness, there was an increment in TG group.

Conclusion

Twelve weeks of aerobic training were neither effective in improving cognitive functioning significantly, nor influential on circulating neurotrophins levels in AD patients.

Acknowledgments

We are thankful to Clarice Sibuya from UNESP for technical aid, CAPES PDSE 99999.010743/2014-06, Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) PDJ 153874/2018-0; Núcleo UNESP-UNATI; Physical activity and the aging lab (LAFE) and Programa de Cinesioterapia Funcional e Cognitiva em Idosos com doença de Alzheimer (PRO-CDA) for support. The English text of this paper has been revised by Sidney Pratt, Canadian, MAT (The Johns Hopkins University), RSAdip - TESL (Cambridge University).

Disclosure statement

No potential conflict of interest was reported by the author(s).

Correction Statement

This article has been corrected with minor changes. These changes do not impact the academic content of the article.

Additional information

Funding

This work was supported by the Fundação de Amparo à Pesquisa do Estado de São Paulo [2013/19729-0]; Fundação de Amparo à Pesquisa do Estado de São Paulo [2012/21286-7]; Fundação de Amparo à Pesquisa do Estado de São Paulo [2011/10051-6].

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