Publication Cover
Hemoglobin
international journal for hemoglobin research
Volume 33, 2009 - Issue 3-4
31
Views
10
CrossRef citations to date
0
Altmetric
Original Article

Sickle Cell Disease Painful Crisis and Steady State Differentiation by Proton Magnetic Resonance

, , , &
Pages 206-213 | Received 04 Oct 2008, Accepted 02 Feb 2009, Published online: 15 Sep 2009
 

Abstract

The delay time of the Hb S polymerization process was investigated in 63 patients with sickle cell disease during steady state and 10 during painful crisis starting from spin–spin proton magnetic resonance (PMR) time behavior measured at 36°C and during spontaneous deoxygenation. We found a significant decrease of delay time as a result of the crisis (36 ± 10%) and two well-differentiated ranges of values for each state: 273–354 min for steady state and 166–229 min for crisis with an uncertainty region of 15%. It is possible to use PMR as an objective and quantitative method in order to differentiate both clinical conditions of the sickle cell patient, but a more clear differentiation can be established comparing the delay time (td) value of one patient during crisis with his own td value during steady state.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,628.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.