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Review Article

A critical review about methodologies for the analysis of mucoadhesive properties of drug delivery systems

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Pages 1053-1070 | Received 22 Dec 2016, Accepted 09 Feb 2017, Published online: 01 Mar 2017
 

Abstract

Mucoadhesion is a useful strategy for drug delivery systems, such as tablets, patches, gels, liposomes, micro/nanoparticles, nanosuspensions, microemulsions and colloidal dispersions. Moreover, it has contributed to many benefits like increased residence time at application sites, drug protection, increased drug permeation and improved drug availability. In this context, investigation into the mucoadhesive properties of pharmaceutical dosage forms is fundamental, in order to characterize, understand and simulate the in vivo interaction between the formulation and the biological substrate, contributing to the development of new mucoadhesive systems with effectiveness, safety and quality. There are a lot of in vivo, in vitro and ex vivo methods for the evaluation of the mucoadhesive properties of drug delivery systems. However, there also is a lack of standardization of these techniques, which makes comparison between the results difficult. Therefore, this work aims to show an overview of the most commonly employed methods for mucoadhesion evaluation, relating them to different proposed systems and using artificial or natural mucosa from humans and animals.

Acknowledgements

The authors acknowledge the Brazilian agency CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior).

Disclosure statement

The authors report no conflicts of interest.

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