Clinical Efficacy of Magnesium Supplementation in Patients with Type 2 Diabetes

Abstract

Effects of magnesium (Mg) supplementation on nine mild type 2 diabetic patients with stable glycemic control were investigated. Water from a salt lake with a high natural Mg content (7.1%) (MAG21) was used for supplementation after dilution with distilled water to 100mg/100mL; 300mL/day was given for 30 days. Fasting serum immunoreactive insulin level decreased significantly, as did HOMA□R (both p < 0.05). There was also a marked decrease of the mean triglyceride level after supplementation. The patients with hypertension showed significant reduction of systolic (p < 0.01), diastolic (p = 0.0038), and mean (p < 0.01) blood pressure. The salt lake water supplement, MAG21, exerted clinical benefit as a Mg supplement in patients with mild type 2 diabetes mellitus.

• magnesium supplementation
• type 2 diabetes mellitus
• hypertension
• insulin-resistance
• hypertriglyceridemia
• life style-related diseases

We thank M. Shiraishi (Department of Clinical Laboratory, Jikei University School of Medicine) and H. Akiyama (SRL Co, Ltd. Tokyo) for performing the assays of materials.