Examining the Vitamin D Status of Children With Solid Tumors

Figures & data

Figure 1. Each different shade of blue column illustrates the number of patients (written on the top) in the certain percentile range (n_{(< 3 pc)}: 26, n_{(3–10 pc)}: 11, n_{(10–25 pc)}: 21, n_{(25–50 pc)}: 23, n_{(50–75 pc)}: 16, n_{(75–90 pc)}: 11, n_{(90–97 pc)}: 13, n_{(> 97 pc)}: 5).

Figure 2. Darker blue: number of patients with serum vitamin D level under the average level; lighter blue: number of patients with serum vitamin D level above the average level; bright point: mean values in each (patient and control) groups.

Figure 3. Blue column: number of children in the patient group. Numbers on the blue columns: the percentage of the patients with the certain vitamin D level in patient group (n_{(< 10 ng/ml)}: 10, n_{(< 20 ng/ml)}: 56, n_{(< 30 ng/ml)}: 60, n_{(> 30 ng/ml)}: 47). Orange: number of children in the control group. Numbers on the orange columns: the percentage of the children with the certain vitamin D level in control group (n_{(< 10 ng/ml)}: 11, n_{(< 20 ng/ml)}: 77, n_{(< 30 ng/ml)}: 210, n_{(> 30 ng/ml)}: 271). Vertical line: vitamin D supplementation reasonable under that (30 ng/ml) serum vitamin D level.

Table 1. Number of patients in different serum vitamin D categories initially.

Initial vitamin D value (ng/ml)	Complete response	Partial response	Stable disease	Progressive disease	Exitus
>30 (sufficiency)	32	3	9	0	3
20–30 (insufficiency)	45	4	2	2	7
10–20 (deficiency)	33	4	4	2	13
<10 (severe deficiency)	6	0	0	1	3
Total	116	11	15	5	26

Table 2. Number of patients in different serum vitamin D categories showing responses to therapy.

Vitamin D-vitamin value reached by treatment (ng/ml)	Complete response	Partial response	Stable disease	Progressive disease	Exitus
>30 (sufficiency)	30	4	2	2	2
20–30 (insufficiency)	51	7	3	2	3
10–20 (deficiency)	10	0	1	1	4
<10 (severe deficiency)	1	1	0	0	1
Total	92	12	6	5	10

   

Figure 4. The percentage of children with lower than 10 ng/ml serum vitamin D levels before and after vitamin D supplementation. The percentage of children with 10–20 ng/ml serum vitamin D levels before and after vitamin D supplementation. The percentage of children with 20–30 ng/ml serum vitamin D levels before and after vitamin D supplementation. The percentage of children with higher than 30 ng/ml serum vitamin D levels before and after vitamin D supplementation.

Figure 5. Blue points: the PTH levels measured at the same time as the adherent serum vitamin D level; Blue line: the linear regression; visualise a negative correlation.