Libraries on Oxetane δ-Amino Acid Scaffolds: Syntheses and Evaluation of Physicochemical and Metabolic Properties

Abstract

Oxetane δ-amino acids were investigated as scaffolds to generate oxetane-based libraries. As pharmacophores, oxadiazoles and triazoles were built up on the scaffolds. Important physicochemical properties of target compounds were predicted in silico, and some physicochemical (solubility, logD, pKa values, permeation through artificial membranes) and metabolic (intrinsic clearance) properties were determined experimentally. The compounds synthesized exhibited the desired ADMETox properties. From an in silico point of view, this work adds valuable information for the refinement of prediction tools.

Keywords:

• Carbohydrate amino acids
• δ-Amino acids
• Oxetanes
• Carbohydrate scaffolds
• Oxadiazoles
• Oxetane
• Triazoles
• Physicochemical properties
• Permeation
• Metabolic properties

ACKNOWLEDGEMENTS

Hans Peter Wessel would like to dedicate this publication to Dr. Malcolm B. Perry, National Research Council of Canada, on the occasion of his retirement and in recognition of his scientific oeuvre.

S. D. Lucas would like to thank Fundação para a Ciência e a Tecnologia for a PhD grant (SFRH/BD/16592/2004).