Phosphorylation of Radix Cyathula officinalis polysaccharide improves its immune-enhancing activity

Abstract

In this study, the effects of phosphorylation of Radix Cyathula officinalis polysaccharide (RCPS) on its immunological properties were evaluated using broiler chickens immunized with Newcastle disease vaccine (NDV). The results suggested that phosphorylated RCPS (pRCPS) could enhance antibody titers against NDV vaccination, improve the indexes of thymus, the bursa of fabricius and spleen, and up-regulate IL-2, IL-4, IL-5, IL-6, IL-10, and IFN-γ. Overall, pRCPS could significantly improve cellular and humoral immune responses in broiler chickens immunized with NDV and thus represents a useful immunotherapeutic agent.

Graphical Abstract

Keywords:

• Phosphorylation
• Cyathulae officinalis polysaccharide
• Newcastle disease vaccine
• immune response
• adjuvant

Disclosure statement

No potential conflict of interest was reported by the authors.

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.

Additional information

Funding

The project was supported by the National Natural Science Foundation of China (Project No. 31872511 and 31402238), in part by the Fundamental Research Funds for the Central Universities (Project No. XDJK2019B015), and in part by the Advanced and Applied Basic Research Program (Project No. cstc2015jcyjA80023).