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Abstract
A ligand-based enzyme-linked immunosorbent assay (ELISA) for the soluble form of functional asialoglycaoprotein receptor (s-ASGPR) in human serum has been developed. This assay was evaluated and proved to show good stability, which is suitable for testing human serum. Clinical serum samples were collected and tested with the established assay. The contents of serum s-ASGPR in healthy group and liver injury group were compared (p < 0.001). The functional s-ASGPR can be a promising candidate of noninvasive biomarker for liver function and injury. The receiver-operating characteristic (ROC) curve analysis illustrated that this economical, sensitive, and reproducible quantitative assay has great potential for clinical use.
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This article has been corrected with minor changes. These changes do not impact the academic content of the article.
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Jian Yin
Dr. Jian YIN finished his BS and MS studies in China, and then obtained PhD from the University of Potsdam, under the supervision of Prof. Dr. Torsten Linker in Germany. After a postdoctoral position with Prof. Dr. Peter H. Seeberger at the MPI of Colloids and Interfaces in Germany, he started his independent research career at Key Laboratory of Carbohydrate Chemistry and Biotechnology (Ministry of Education), School of Biotechnology, Jiangnan University from 2012 in China. His research interests include synthesis of oligosaccharides and glycoconjugates, as well as the novel development of carbohydrate-based drugs and vaccines