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Cancer Investigation Volume 26, 2008 - Issue 7
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ORIGINAL ARTICLESCellular and Molecular Biology

The Effect of Dalteparin, a Kind of Low Molecular Weight Heparin, on Lung Adenocarcinoma A549 Cell Line In Vitro

Xiaojun Chen Department of Respiratory Diseases, Qilu Hospital, Shandong University, Jinan, Shandong, P.R. China
,
Wei Xiao Department of Respiratory Diseases, Qilu Hospital, Shandong University, Jinan, Shandong, P.R. China
,
Xun Qu Institute of Basic Medical Sciences, Qilu Hospital, Shandong University, Jinan, Shandong, P.R. China
&
Shengyu Zhou Department of Respiratory Diseases, Qilu Hospital, Shandong University, Jinan, Shandong, P.R. China
Pages 718-724 | Published online: 11 Jun 2009
 
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Abstract

The beneficial effects of unfractionated heparin and low molecular weight heparin on cancer progression have been reported. In the study, the effect of dalteparin on pulmonary adenocarcinoma A549 cell line was observed in vitro. Our experiments revealed that: (Citation) dalteparin can inhibit the cell viability dose-dependently and time-dependently; (Citation) dalteparin can arrest the A549 cells in G1 phase and induce them to early apoptosis; (Citation) dalteparin exerts its effects through p21WAF1 and p27KIP1 proteins; and (Citation) the changes of p21WAF1 and p27KIP1 proteins caused by dalteparin occurred at posttranscriptional levels.

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