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Cancer Investigation Volume 36, 2018 - Issue 4
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Articles

High tRNA Transferase NSUN2 Gene Expression is Associated with Poor Prognosis in Head and Neck Squamous Carcinoma

Lingeng LuDepartment of Chronic Disease Epidemiology, School of Public Health, School of Medicine, Center for Biomedical Data Science, Yale Cancer Center, Yale University, New Haven, Connecticut, USACorrespondence[email protected]
,
Gongjian ZhuGansu Provincial Academy of Medical Science, Gansu Provincial Cancer Hospital, Lanzhou, China
,
Hongmei ZengNational Office for Cancer Prevention and Control, Cancer Hospital, Chinese Academy of Medical Sciences/National Cancer Center, Beijing, China
,
Qian XuKey Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China
&
Klaus HolzmannDivision of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Austria
Pages 246-253 | Received 16 Oct 2017, Accepted 16 Apr 2018, Published online: 18 May 2018
 
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ABSTRACT

NSUN2 is a tRNA methyltransferase and plays an important role in cell development via modifying RNA methylation. We aimed to evaluate the expression of NSUN2 and its prognostic value in HNSCC. Random-effects model of meta-analysis shows 1.99-folds (95% CI: 1.89–2.09) upregulation of NSUN2 expression in HNSCC versus normal tissues. Patients with high NSUN2 levels had approximately 22 months shorter overall survival, and had a higher mortality risk than those with low one (p-trend = 0.020). In conclusion, NSUN2 is a potential independent prognostic marker and may be a potential therapeutic target in HNSCC.

Conflict of interest

The authors report no declaration of interest.

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