Abstract
This study aimed to determine the main single nucleotide polymorphisms (SNPs) that are associated with an increased or decreased risk of glioma development in healthy individuals. We conducted a systematic review of the articles published in English on the PUBMED database between January 2008 and December 2017. Our search resulted in a total of 743 articles; however, only 56 were included in this review. A total of 148 polymorphisms were found, which involved 64 different genes. The polymorphisms that were most associated with an increased risk of glioma development were polymorphic variants rs179782, rs13181, and rs3791679 of the genes XRCC1, ERCC2, and EFEMP1, respectively.
Author contributions
CBT and BBS conceived the idea and wrote manuscript. FCSGB, EBS, JNPOB, MAM, VC, FMN, RMLA, IMK, LMS Jr, LCCF, and YQA critically reviewed the article and supervised the project.
Disclosure statement
The authors disclose that they have no competing interests.