Advanced search
Publication Cover
Cancer Investigation Volume 42, 2024 - Issue 6
Submit an article Journal homepage
246
Views
0
CrossRef citations to date
0
Altmetric
Research Articles

A Bioinformatic Analysis of Gut Microbiota Related with Immune Cell Infiltration in Colorectal Cancer

Dan Liua Department of Ultrasound Imaging, Zhuhai People’s Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, ChinaView further author information
,
Jiang Zhoub Department of Medicine, Tianjin Georigin Biology Co., Ltd, Tianjin, ChinaView further author information
,
Qiong Fua Department of Ultrasound Imaging, Zhuhai People’s Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, ChinaView further author information
,
Yuanzhu Zhaoa Department of Ultrasound Imaging, Zhuhai People’s Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, ChinaView further author information
,
Panpan Wanga Department of Ultrasound Imaging, Zhuhai People’s Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, ChinaView further author information
,
Yang Zhenga Department of Ultrasound Imaging, Zhuhai People’s Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, ChinaView further author information
,
Meihong Cuia Department of Ultrasound Imaging, Zhuhai People’s Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, ChinaView further author information
&
Heng Zhanga Department of Ultrasound Imaging, Zhuhai People’s Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-2028-1538View further author information
ORCID Icon show all
Pages 491-499 | Received 03 Jan 2023, Accepted 11 Jun 2024, Published online: 21 Jun 2024

Figures & data

Figure 1. Top 50 abundances of microbiotas for GSVA. The GSVA analysis (Gene Set Variant Analysis) for the relationship between microbiota and immune cells. The abscissa represents top 50 abundances of microbiotas and the ordinate represents difference of immune cells infiltration between high and low microbiota group. If the difference is positive, it will be red, otherwise it will be blue. If no difference exists, it is yellow.

Figure 1. Top 50 abundances of microbiotas for GSVA. The GSVA analysis (Gene Set Variant Analysis) for the relationship between microbiota and immune cells. The abscissa represents top 50 abundances of microbiotas and the ordinate represents difference of immune cells infiltration between high and low microbiota group. If the difference is positive, it will be red, otherwise it will be blue. If no difference exists, it is yellow.

Figure 2. Top 50 abundances of microbiotas for CIB. The CIBERSORT analysis for the relationship between microbiota and immune cells. The abscissa represents top 50 abundances of microbiotas and the ordinate represents immune cells. If the difference between microbiota and immune cells is positive, it will be red, otherwise it will be blue. If no difference exists, it is yellow.

Figure 2. Top 50 abundances of microbiotas for CIB. The CIBERSORT analysis for the relationship between microbiota and immune cells. The abscissa represents top 50 abundances of microbiotas and the ordinate represents immune cells. If the difference between microbiota and immune cells is positive, it will be red, otherwise it will be blue. If no difference exists, it is yellow.

Figure 3. Top 50 abundances of microbiotas for Immune genes. Analysis for the relationship between microbiota and immune genes. The abscissa represents top 50 abundances of microbiotas and the ordinate represents immune genes. If the difference between microbiota and immune genes is positive, it will be red, otherwise it will be blue. If no difference exists, it is yellow.

Figure 3. Top 50 abundances of microbiotas for Immune genes. Analysis for the relationship between microbiota and immune genes. The abscissa represents top 50 abundances of microbiotas and the ordinate represents immune genes. If the difference between microbiota and immune genes is positive, it will be red, otherwise it will be blue. If no difference exists, it is yellow.

Table 1. Immune-related genes.

Figure 4. The Venn diagram and list of overlapping microbiota groups appeared in the four analyses. Microbiota groups that appeared simultaneously in the four analyses did not exist, and a total of 8 microbiota groups appeared in the three analyses.

Figure 4. The Venn diagram and list of overlapping microbiota groups appeared in the four analyses. Microbiota groups that appeared simultaneously in the four analyses did not exist, and a total of 8 microbiota groups appeared in the three analyses.

Figure 5. Expression analysis of microbial populations according to clinical parameter (CRC_STAGE) were performed by using ANOVA.

Figure 5. Expression analysis of microbial populations according to clinical parameter (CRC_STAGE) were performed by using ANOVA.

Figure 6. Expression analysis of microbial populations according to clinical parameter (FAMILY_HISTORY_CRC_Magnetospirillum) were performed by using Mann-Whitney U test.

Figure 6. Expression analysis of microbial populations according to clinical parameter (FAMILY_HISTORY_CRC_Magnetospirillum) were performed by using Mann-Whitney U test.

Figure 7. Expression analysis of microbial populations according to clinical parameter (BMI_Varibaculum) were performed by using Mann-Whitney U test.

Figure 7. Expression analysis of microbial populations according to clinical parameter (BMI_Varibaculum) were performed by using Mann-Whitney U test.

Figure 8. Expression analysis of microbial populations according to clinical parameter (BMI_Eggerthella) were performed by using Mann-Whitney U test.

Figure 8. Expression analysis of microbial populations according to clinical parameter (BMI_Eggerthella) were performed by using Mann-Whitney U test.
Supplemental material

Supplemental Material

Download PDF (5.8 MB)

Data availability statement

All data sets for this study are included in the GEO (https://www.ncbi.nlm.nih.gov/geo/) GSE165255 dataset for the database.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.