On developing a novel mixed-unit microparticle system for controlled release

ABSTRACT

In this study, uniform microparticles were prepared using the highly efficient microfluidic spray drying technology, and then a flexible controlled release mixed-unit microparticle system was developed to meet various needs. A mathematical drug release model of the mixed system was established and two mixed formulations were used to testify the predictive ability when initial parameters were given. Results have proved that the proposed model could precisely predict the release rate of tested samples. In conclusion, the novel system for controlled release may provide a new option for modified release drugs and may have a good prospect in the industrial application.

KEYWORDS:

• Controlled release
• matrix composition
• microfluidic jet spray drying
• mixed-unit microparticle system
• modeling

Abbreviations::

• AIC: Akaike information criterion
• PXRD: powder X-ray diffraction
• : adjusted goodness-of-fit
• SEM: scanning electron microscopy
• VB₁₂: vitamin B₁₂

Additional information

Funding

The project was funded by National Natural Science Foundation of China (Grant No. 81503023) and International Postdoctoral Exchange Fellowship Program of Central South University (Grant No. 149945).