The day-night pattern of colonic contractility is not impaired in type 1 diabetes and distal symmetric polyneuropathy

Figures & data

Table 1. Participant characteristics of the control group (CON), type 1 diabetes without DSPN (T1D/-DSPN), and type 1 diabetes with DSPN(T1D/+DSPN). Data are presented as median [Q1, Q3] unless otherwise stated. BMI, body mass index; BPM, beats/min; HbA1c, Hemoglobin A1c; DSPN, distal symmetric polyneuropathy; T1D, type 1 diabetes; CON, control group

	CON	T1D/-DSPN	T1D/+DSPN	P-value
n	28	40	35
Age (y)	52 [45, 57]	38 [28, 51]	50 [44, 56]	0.005
Women, number (%)	15 (54)	19 (48)	23 (66)	0.022
Height (cm)	175 [169, 182]	174 [167, 177]	180 [174, 184]	0.001
Weight (kg)	70.0 [64.0, 82.3]	74.3 [66.2, 85.1]	85.3 [77.6, 97.4]	<0.001
BMI (kg/m^2)	23.7 [22.0, 24.6]	25.5 [23.4, 27.3]	27.5 [25.2, 30.0]	<0.001
Smokers, number (%)	3 (11)	11 (28)	5 (14)	0.358
Systolic blood pressure (mmHg)	124 [112, 130]	130 [120, 142]	140 [124, 154]	0.001
Diastolic blood pressure (mmHg)	73 [70, 84]	74 [67, 80]	77 [73, 83]	0.032
Resting heart rate (BPM)	66 [59, 74]	69 [63, 76]	73 [70, 79]	0.043
HbA1c (%)	5.3 [5.2, 5.4]	7.5 [7.0, 8.5]	8.1 [7.6, 8.7]	<0.001
HbA1c (mmol/mol)	34 [33, 36]	58 [53, 69]	65 [60, 72]	<0.001
Disease duration (years)	0 [0, 0]	20 [11, 28]	31 [25, 40]	<0.001
Wake up time (h:min)	06:45 [06:15, 07:00]	07:00 [06:00, 08:00]	06:30 [06:00, 07:15]	0.529
Bedtime (h:min)	22:30 [22:00, 23:00]	22:30 [22:00, 23:15]	23:00 [22:30, 23:30]	0.044

Figure 1. Box and whisker plots demonstrating max amplitude (a), mean peak amplitude (b), mean contraction (c), and motility index (d) in the control group (CON) (evening: n = 25, night: n = 28, morning: n = 23), type 1 diabetes without DSPN (T1D/-DSPN) (evening: n = 36, night: n = 36, morning: n = 26), and type 1 diabetes with DSPN (T1D/+DSPN) (evening: n = 30, night: n = 32, morning: n = 30). Purple boxes = CON, teal boxes = T1D/+DSPN, yellow boxes = T1D/-DSPN. Effect of group adjusted for sex and age was assessed by one-way ANOVA at each time-point, and a Tukey post-hoc test was applied to asses between-group differences. Overall effect of group is marked by a line with p-value. DSPN, distal symmetric polyneuropathy; T1D, type 1 diabetes; CON, control group

Figure 2. Box and whisker plots demonstrating delta values calculated as morning/night of max amplitude (a), mean peak amplitude (b), mean contraction (c), and motility index (d) in the control group (CON: n = 23), type 1 diabetes without DSPN (T1D/-DSPN: n = 22), and type 1 diabetes with DSPN (T1D/+DSPN: n = 27). Purple boxes = CON, teal boxes = T1D/+DSPN, yellow boxes = T1D/-DSPN. Effect of group adjusted for sex and age was assessed by one-way ANOVA at each time-point. DSPN, distal symmetric polyneuropathy; T1D, type 1 diabetes; CON, control group